Caging the Beast: TRIM5α Binding to the HIV-1 Core
The potent HIV-1 inhibitor TRIM5α blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5α is known to form higher-order self-association complexes that contribute to the avidity of TRIM5α for the HIV-1 capsid, and are essential to inhibit infection; these higher-order self-association...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-04-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/3/5/423/ |