Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study
Abstract Background To investigate the clinical features and risk factors of ventriculoperitoneal shunt (VPS) associated surgical site infections (SSIs) in HIV-negative patients with cryptococcal meningitis (CM). Methods We retrospectively reviewed the medical records of HIV-negative patients with C...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07719-2 |
| _version_ | 1818022361479249920 |
|---|---|
| author | Lejia Xu Jianyun Zhu Xiaoyun Wang Guofen Zeng Zhiliang Gao Jing Liu |
| author_facet | Lejia Xu Jianyun Zhu Xiaoyun Wang Guofen Zeng Zhiliang Gao Jing Liu |
| author_sort | Lejia Xu |
| collection | DOAJ |
| description | Abstract Background To investigate the clinical features and risk factors of ventriculoperitoneal shunt (VPS) associated surgical site infections (SSIs) in HIV-negative patients with cryptococcal meningitis (CM). Methods We retrospectively reviewed the medical records of HIV-negative patients with CM underwent VPS operation admitted to The Third Affiliated Hospital of Sun Yat-sen University in Southwest China over the past 7 years. Results 193 patients were included, of whom 25 (12.95%) had SSIs in 6 (median duration, 1–48 days) days after operation. Compared with patients without SSIs, patient with SSIs tended to be shorter preoperative stay. 52% patients in SSIs group and 25% patients in no-SSIs group underwent VPS operations within 3 days after admission (p = 0.017). Although body temperature and infectious indicators slightly elevated postoperative in both groups. The patients with SSIs experienced more fever; more central nervous system symptoms; higher PCT value and lower cerebrospinal fluid (CSF) glucose in contrast to the no-SSIs group. Multivariate regression analysis found a 2.653 fold increase in the risk of infection for every 1 °C increase in postoperative body temperature. Among the 25 patients, 9 patients had positive culture results, three samples reported to be oxacillin resistant coagulase-negative Staphylococci. Conclusions SSIs was one of the serious surgical complications after VPS operation. High body temperature, the occurrence of dizziness and headache, low postoperative hemoglobin are risk factors. Postoperative patients with high fever, high PCT and low CSF glucose should be paid more attention to. |
| first_indexed | 2024-04-14T08:31:30Z |
| format | Article |
| id | doaj.art-c7f1567dce2d4daf8742c372081ae7b3 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-14T08:31:30Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c7f1567dce2d4daf8742c372081ae7b32022-12-22T02:03:54ZengBMCBMC Infectious Diseases1471-23342022-09-012211810.1186/s12879-022-07719-2Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective studyLejia Xu0Jianyun Zhu1Xiaoyun Wang2Guofen Zeng3Zhiliang Gao4Jing Liu5Department of Pharmacy, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen UniversityAbstract Background To investigate the clinical features and risk factors of ventriculoperitoneal shunt (VPS) associated surgical site infections (SSIs) in HIV-negative patients with cryptococcal meningitis (CM). Methods We retrospectively reviewed the medical records of HIV-negative patients with CM underwent VPS operation admitted to The Third Affiliated Hospital of Sun Yat-sen University in Southwest China over the past 7 years. Results 193 patients were included, of whom 25 (12.95%) had SSIs in 6 (median duration, 1–48 days) days after operation. Compared with patients without SSIs, patient with SSIs tended to be shorter preoperative stay. 52% patients in SSIs group and 25% patients in no-SSIs group underwent VPS operations within 3 days after admission (p = 0.017). Although body temperature and infectious indicators slightly elevated postoperative in both groups. The patients with SSIs experienced more fever; more central nervous system symptoms; higher PCT value and lower cerebrospinal fluid (CSF) glucose in contrast to the no-SSIs group. Multivariate regression analysis found a 2.653 fold increase in the risk of infection for every 1 °C increase in postoperative body temperature. Among the 25 patients, 9 patients had positive culture results, three samples reported to be oxacillin resistant coagulase-negative Staphylococci. Conclusions SSIs was one of the serious surgical complications after VPS operation. High body temperature, the occurrence of dizziness and headache, low postoperative hemoglobin are risk factors. Postoperative patients with high fever, high PCT and low CSF glucose should be paid more attention to.https://doi.org/10.1186/s12879-022-07719-2Cryptococcal meningitisVentriculoperitoneal shuntHIV-negativeSurgical site infectionsIntracranial hypertension |
| spellingShingle | Lejia Xu Jianyun Zhu Xiaoyun Wang Guofen Zeng Zhiliang Gao Jing Liu Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study BMC Infectious Diseases Cryptococcal meningitis Ventriculoperitoneal shunt HIV-negative Surgical site infections Intracranial hypertension |
| title | Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study |
| title_full | Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study |
| title_fullStr | Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study |
| title_full_unstemmed | Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study |
| title_short | Clinical features and risk factors of surgical site infections in HIV-negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations: a retrospective study |
| title_sort | clinical features and risk factors of surgical site infections in hiv negative patients with cryptococcal meningitis underwent ventriculoperitoneal shunt operations a retrospective study |
| topic | Cryptococcal meningitis Ventriculoperitoneal shunt HIV-negative Surgical site infections Intracranial hypertension |
| url | https://doi.org/10.1186/s12879-022-07719-2 |
| work_keys_str_mv | AT lejiaxu clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy AT jianyunzhu clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy AT xiaoyunwang clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy AT guofenzeng clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy AT zhilianggao clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy AT jingliu clinicalfeaturesandriskfactorsofsurgicalsiteinfectionsinhivnegativepatientswithcryptococcalmeningitisunderwentventriculoperitonealshuntoperationsaretrospectivestudy |