The Effect of Enteral Nutrition with Low-Dose Lactulose on the Occurrence of Late-Onset Neonatal Sepsis in Infants with Very Low Birth Weight
Background: This study aimed to investigate the effect of low-dose lactulose as a prebiotic on the prevention of sepsis in infants with very low birth weight. Methods: In a clinical trial study, 50 infants with very low birth weight were selected, and randomly divided into two groups of 25. The fir...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2019-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/10919 |
| Summary: | Background: This study aimed to investigate the effect of low-dose lactulose as a prebiotic on the prevention of sepsis in infants with very low birth weight.
Methods: In a clinical trial study, 50 infants with very low birth weight were selected, and randomly divided into two groups of 25. The first group received low-dose lactulose feeding, and the second group received distilled water feeding as placebo. The frequency of late-onset neonatal sepsis was determined and compared between the two groups.
Findings: Late onset neonatal sepsis was seen in 14.8% and 40.0% of infants in lactulose and placebo group, respectively (P = 0.040). Moreover, the time to reach full dose enteral nutrition was significantly shorter in the lactulose group (12.85 ± 3.33 days) compared to placebo group (15.20 ± 5.24 days) (P = 0.030).
Conclusion: As a prebiotic in infants with very low birth weight, lactulose feeding is beneficial and without side effects in late-onset neonatal sepsis. These findings show the possible beneficial effects of prebiotics, and requires further studies with larger sample sizes. |
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| ISSN: | 1027-7595 1735-854X |