<i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely <i&g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/17/5450 |
| _version_ | 1797494204679585792 |
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| author | Federico Cuccu Francesco Basoccu Claudia Fattuoni Andrea Porcheddu |
| author_facet | Federico Cuccu Francesco Basoccu Claudia Fattuoni Andrea Porcheddu |
| author_sort | Federico Cuccu |
| collection | DOAJ |
| description | The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely <i>N</i>-formylsaccharin, <i>N</i>-acetylsaccharin, and <i>N</i>-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup. |
| first_indexed | 2024-03-10T01:31:00Z |
| format | Article |
| id | doaj.art-c7f2cc5314b04ab6910ba1ded2574b43 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:31:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c7f2cc5314b04ab6910ba1ded2574b432023-11-23T13:42:07ZengMDPI AGMolecules1420-30492022-08-012717545010.3390/molecules27175450<i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in MechanochemistryFederico Cuccu0Francesco Basoccu1Claudia Fattuoni2Andrea Porcheddu3Department of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, ItalyDepartment of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, ItalyDepartment of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, ItalyDepartment of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, ItalyThe acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely <i>N</i>-formylsaccharin, <i>N</i>-acetylsaccharin, and <i>N</i>-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.https://www.mdpi.com/1420-3049/27/17/5450formamidesgreen chemistryball millingmechanochemistrysaccharin |
| spellingShingle | Federico Cuccu Francesco Basoccu Claudia Fattuoni Andrea Porcheddu <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry Molecules formamides green chemistry ball milling mechanochemistry saccharin |
| title | <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry |
| title_full | <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry |
| title_fullStr | <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry |
| title_full_unstemmed | <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry |
| title_short | <i>N</i>-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry |
| title_sort | i n i formylsaccharin a sweet able formylating agent in mechanochemistry |
| topic | formamides green chemistry ball milling mechanochemistry saccharin |
| url | https://www.mdpi.com/1420-3049/27/17/5450 |
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