Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea
OBJECTIVES Elevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life ev...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2021-06-01
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| Series: | Epidemiology and Health |
| Subjects: | |
| Online Access: | http://www.e-epih.org/upload/pdf/epih-43-e2021042.pdf |
| _version_ | 1828915067068874752 |
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| author | Naharin Sultana Anni Sun Jae Jung Jee-Seon Shim Yong Woo Jeon Ga Bin Lee Hyeon Chang Kim |
| author_facet | Naharin Sultana Anni Sun Jae Jung Jee-Seon Shim Yong Woo Jeon Ga Bin Lee Hyeon Chang Kim |
| author_sort | Naharin Sultana Anni |
| collection | DOAJ |
| description | OBJECTIVES Elevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on serum triglyceride levels in the healthy population. Therefore, we evaluated the independent association between SLEs and serum triglyceride levels in a middle-aged Korean population. METHODS We analyzed a sample of 2,963 people (aged 30-64 years; 36% men) using baseline data from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort study. The Korean version of the Life Experience Survey questionnaire was used to measure the presence and positive/negative impact of SLEs. Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL. RESULTS Of the 2,963 participants, 33.1% reported at least 1 SLE over the past 6 months and 24.8% had hypertriglyceridemia. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was also associated with having 4 or more SLEs with positive effects (odds ratio [OR], 2.57; 95% CI, 1.02 to 6.46) and 4 or more SLEs with negative effects (OR, 1.99; 95% CI, 1.16 to 3.41) in men. CONCLUSIONS Our findings suggest that SLEs may increase the risk of hypertriglyceridemia in middle-aged men. |
| first_indexed | 2024-12-13T20:06:46Z |
| format | Article |
| id | doaj.art-c7f43092bb204523a0bc5bad4947037f |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-12-13T20:06:46Z |
| publishDate | 2021-06-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-c7f43092bb204523a0bc5bad4947037f2022-12-21T23:33:00ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932021-06-014310.4178/epih.e20210421187Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in KoreaNaharin Sultana Anni0Sun Jae Jung1Jee-Seon Shim2Yong Woo Jeon3Ga Bin Lee4Hyeon Chang Kim5 Department of Public Health, Graduate School, Yonsei University, Seoul, Korea Department of Public Health, Graduate School, Yonsei University, Seoul, Korea Department of Public Health, Graduate School, Yonsei University, Seoul, Korea Department of Public Health, Graduate School, Yonsei University, Seoul, Korea Department of Public Health, Graduate School, Yonsei University, Seoul, Korea Department of Public Health, Graduate School, Yonsei University, Seoul, KoreaOBJECTIVES Elevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on serum triglyceride levels in the healthy population. Therefore, we evaluated the independent association between SLEs and serum triglyceride levels in a middle-aged Korean population. METHODS We analyzed a sample of 2,963 people (aged 30-64 years; 36% men) using baseline data from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort study. The Korean version of the Life Experience Survey questionnaire was used to measure the presence and positive/negative impact of SLEs. Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL. RESULTS Of the 2,963 participants, 33.1% reported at least 1 SLE over the past 6 months and 24.8% had hypertriglyceridemia. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was also associated with having 4 or more SLEs with positive effects (odds ratio [OR], 2.57; 95% CI, 1.02 to 6.46) and 4 or more SLEs with negative effects (OR, 1.99; 95% CI, 1.16 to 3.41) in men. CONCLUSIONS Our findings suggest that SLEs may increase the risk of hypertriglyceridemia in middle-aged men.http://www.e-epih.org/upload/pdf/epih-43-e2021042.pdfpsychological stresslipidshypertriglyceridemia |
| spellingShingle | Naharin Sultana Anni Sun Jae Jung Jee-Seon Shim Yong Woo Jeon Ga Bin Lee Hyeon Chang Kim Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea Epidemiology and Health psychological stress lipids hypertriglyceridemia |
| title | Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea |
| title_full | Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea |
| title_fullStr | Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea |
| title_full_unstemmed | Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea |
| title_short | Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea |
| title_sort | stressful life events and serum triglyceride levels the cardiovascular and metabolic diseases etiology research center cohort in korea |
| topic | psychological stress lipids hypertriglyceridemia |
| url | http://www.e-epih.org/upload/pdf/epih-43-e2021042.pdf |
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