Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study
Rongfeng Han, Yang Zhang, Xia Jiang Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of ChinaCorrespondence: Rongfeng Han, Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of China, Email hanmenghappy@126.com...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/relationship-between-four-non-insulin-based-indexes-of-insulin-resista-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797756666081443840 |
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| author | Han R Zhang Y Jiang X |
| author_facet | Han R Zhang Y Jiang X |
| author_sort | Han R |
| collection | DOAJ |
| description | Rongfeng Han, Yang Zhang, Xia Jiang Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of ChinaCorrespondence: Rongfeng Han, Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of China, Email hanmenghappy@126.comAim: The aim of this study was to investigate the association between serum uric acid (SUA) levels and four insulin resistance surrogates in patients with type 2 diabetes (T2DM). The four non-insulin-based indexes of insulin resistance (IR) include the glucose and triglycerides index (TyG), TyG index with body mass index (TyG-BMI), ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and metabolic score for insulin resistance (METS-IR).Methods: A total of 687 patients with T2DM were enrolled in the current study. Patients were stratified into three groups according to their levels of SUA. Spearman correlation was used to analyze the correlation between SUA and clinical variables. Multiple linear regression analysis was used to assess the association between SUA and the four insulin resistance surrogates. Receiver operating characteristic (ROC) analyses and the area under the ROC curve (AUC) were then used to assess the ability of TyG, TyG-BMI, TG/HDL-c, and METS-IR to discriminate hyperuricemia (HUA) in T2DM.Results: SUA in T2DM was significantly positively correlated with TyG (r 0.406 P < 0.01), TyG-BMI (r 0.272 P < 0.01), TG/HDL-c (r 0.493 P < 0.01), and METS-IR (r 0.238 P < 0.01). Furthermore, higher values of the four insulin resistance surrogates were independently correlated with higher SUA levels in T2DM patients (P < 0.01 for all) after adjusting for confounding factors. TyG, TyG-BMI, TG/HDL-c, and METS-IR all had a significant discriminative ability for HUA in patients with T2DM. The AUC values were 0.693 (95% CI 0.645– 0.741), 0.649 (95% CI 0.599– 0.699), 0.768 (95% CI 0.726– 0.811), and 0.660 (95% CI 0.609– 0.710), respectively.Conclusion: The present study suggests that TyG, TyG-BMI, TG/HDL-c and METS-IR had a significant correlation with SUA in T2DM. TG/HDL-c was the best marker among the four insulin resistance surrogates for the identification of HUA in T2DM.Keywords: type 2 diabetes, serum uric acid, insulin resistance, TyG, TyG-BMI, TG/HDL-c, METS-IR |
| first_indexed | 2024-03-12T18:04:47Z |
| format | Article |
| id | doaj.art-c7f50aaa776f4242b65664a352a40fec |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T18:04:47Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-c7f50aaa776f4242b65664a352a40fec2023-08-02T09:30:15ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-05-01Volume 151461147175149Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional StudyHan RZhang YJiang XRongfeng Han, Yang Zhang, Xia Jiang Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of ChinaCorrespondence: Rongfeng Han, Department of Endocrinology, Tianjin First Center Hospital, Tianjin, 300192, People’s Republic of China, Email hanmenghappy@126.comAim: The aim of this study was to investigate the association between serum uric acid (SUA) levels and four insulin resistance surrogates in patients with type 2 diabetes (T2DM). The four non-insulin-based indexes of insulin resistance (IR) include the glucose and triglycerides index (TyG), TyG index with body mass index (TyG-BMI), ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and metabolic score for insulin resistance (METS-IR).Methods: A total of 687 patients with T2DM were enrolled in the current study. Patients were stratified into three groups according to their levels of SUA. Spearman correlation was used to analyze the correlation between SUA and clinical variables. Multiple linear regression analysis was used to assess the association between SUA and the four insulin resistance surrogates. Receiver operating characteristic (ROC) analyses and the area under the ROC curve (AUC) were then used to assess the ability of TyG, TyG-BMI, TG/HDL-c, and METS-IR to discriminate hyperuricemia (HUA) in T2DM.Results: SUA in T2DM was significantly positively correlated with TyG (r 0.406 P < 0.01), TyG-BMI (r 0.272 P < 0.01), TG/HDL-c (r 0.493 P < 0.01), and METS-IR (r 0.238 P < 0.01). Furthermore, higher values of the four insulin resistance surrogates were independently correlated with higher SUA levels in T2DM patients (P < 0.01 for all) after adjusting for confounding factors. TyG, TyG-BMI, TG/HDL-c, and METS-IR all had a significant discriminative ability for HUA in patients with T2DM. The AUC values were 0.693 (95% CI 0.645– 0.741), 0.649 (95% CI 0.599– 0.699), 0.768 (95% CI 0.726– 0.811), and 0.660 (95% CI 0.609– 0.710), respectively.Conclusion: The present study suggests that TyG, TyG-BMI, TG/HDL-c and METS-IR had a significant correlation with SUA in T2DM. TG/HDL-c was the best marker among the four insulin resistance surrogates for the identification of HUA in T2DM.Keywords: type 2 diabetes, serum uric acid, insulin resistance, TyG, TyG-BMI, TG/HDL-c, METS-IRhttps://www.dovepress.com/relationship-between-four-non-insulin-based-indexes-of-insulin-resista-peer-reviewed-fulltext-article-DMSOtype 2 diabetesserum uric acidinsulin resistancetygtyg-bmitg/hdl-cmets-ir |
| spellingShingle | Han R Zhang Y Jiang X Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study Diabetes, Metabolic Syndrome and Obesity type 2 diabetes serum uric acid insulin resistance tyg tyg-bmi tg/hdl-c mets-ir |
| title | Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_full | Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_fullStr | Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_full_unstemmed | Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_short | Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study |
| title_sort | relationship between four non insulin based indexes of insulin resistance and serum uric acid in patients with type 2 diabetes a cross sectional study |
| topic | type 2 diabetes serum uric acid insulin resistance tyg tyg-bmi tg/hdl-c mets-ir |
| url | https://www.dovepress.com/relationship-between-four-non-insulin-based-indexes-of-insulin-resista-peer-reviewed-fulltext-article-DMSO |
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