Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease
Cushing's disease is caused by excessive secretion of adrenocorticotropic hormone (ACTH) by hormone-secreting pituitary adenomas, the first-choice treatment for which is surgical resection of the pituitary adenoma. Medication therapy is the second-line treatment, and a necessary treatment f...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-05-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1649303613379-1396165756.pdf |
| _version_ | 1797217195484250112 |
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| author | Ling LI, Huijuan ZHANG |
| author_facet | Ling LI, Huijuan ZHANG |
| author_sort | Ling LI, Huijuan ZHANG |
| collection | DOAJ |
| description | Cushing's disease is caused by excessive secretion of adrenocorticotropic hormone (ACTH) by hormone-secreting pituitary adenomas, the first-choice treatment for which is surgical resection of the pituitary adenoma. Medication therapy is the second-line treatment, and a necessary treatment for some patients with unsatisfactory surgical results or failing to use the surgery. With recent developments in pathogenesis studies of Cushing's disease, medications specifically targeting hormone-secreting pituitary adenomas have proven to be effective in controlling the tumor growth, and suppressing the tumor's secretion of ACTH, which may be a theoretical and practical basis for medical treatment of Cushing's disease. In this review, we discussed pituitary-directed medical therapies for Cushing's disease and their mechanisms of actions, aiming to increase medical workers' understanding of this disease, and to offer theoretical evidence for the development of appropriate treatment strategies. |
| first_indexed | 2024-04-24T11:58:00Z |
| format | Article |
| id | doaj.art-c7f56e4bf50d44808b45a3412489c354 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:58:00Z |
| publishDate | 2022-05-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-c7f56e4bf50d44808b45a3412489c3542024-04-09T03:12:56ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-05-0125141789179410.12114/j.issn.1007-9572.2021.01.039Recent Developments in Pituitary-directed Medical Treatment for Cushing's DiseaseLing LI, Huijuan ZHANG0Department of Endocrinology and Metabolism, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, ChinaCushing's disease is caused by excessive secretion of adrenocorticotropic hormone (ACTH) by hormone-secreting pituitary adenomas, the first-choice treatment for which is surgical resection of the pituitary adenoma. Medication therapy is the second-line treatment, and a necessary treatment for some patients with unsatisfactory surgical results or failing to use the surgery. With recent developments in pathogenesis studies of Cushing's disease, medications specifically targeting hormone-secreting pituitary adenomas have proven to be effective in controlling the tumor growth, and suppressing the tumor's secretion of ACTH, which may be a theoretical and practical basis for medical treatment of Cushing's disease. In this review, we discussed pituitary-directed medical therapies for Cushing's disease and their mechanisms of actions, aiming to increase medical workers' understanding of this disease, and to offer theoretical evidence for the development of appropriate treatment strategies.https://www.chinagp.net/fileup/1007-9572/PDF/1649303613379-1396165756.pdfcushing syndrome|adrenocorticotropic hormone|drug therapy|review |
| spellingShingle | Ling LI, Huijuan ZHANG Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease Zhongguo quanke yixue cushing syndrome|adrenocorticotropic hormone|drug therapy|review |
| title | Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease |
| title_full | Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease |
| title_fullStr | Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease |
| title_full_unstemmed | Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease |
| title_short | Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease |
| title_sort | recent developments in pituitary directed medical treatment for cushing apos s disease |
| topic | cushing syndrome|adrenocorticotropic hormone|drug therapy|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1649303613379-1396165756.pdf |
| work_keys_str_mv | AT linglihuijuanzhang recentdevelopmentsinpituitarydirectedmedicaltreatmentforcushingapossdisease |