Peculiarities of distribution of HLA class I antigens in patients with lihen planus
The article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus. Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2021-03-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://vestnikdv.ru/jour/article/viewFile/1151/1163 |
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| author | Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro |
| author_facet | Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro |
| author_sort | Irina I. Zakhur |
| collection | DOAJ |
| description | The article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus.
Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the HLA class I.
Material and methods. Laboratory analysis of the distribution of HLA class I antigens was carried out in 60 patients with various forms of lichen planus who consider themselves Russian on the basis of linguistic and ethnicity. The duration of the disease is 120 years.
Results. When analyzing the typing results in the general group of patients; a tendency to negative association of HLA-A11 and HLA-B7.
It was found that the frequency of haplotype combinations A1-B8; A2-B27; A2-B40; A3-B35 significantly exceeded that of healthy people. Analysis of the frequency of phenotypic combinations revealed a significant increase in A3-A19 and B12-B35.
Conclusion. Haplotype and phenotypic combinations of HLA A1-B8; A2-B27; A2-B40; A3-B35; A3-A19; B12-B35 are provoking factors in the development of various forms of the disease. The presence of these genetic traits in the individual increases the risk of developing lichen planus by 311 times. In turn; the HLA-A11 and B7 antigens play a protective role. |
| first_indexed | 2024-03-12T08:44:15Z |
| format | Article |
| id | doaj.art-c7f8adf9de2c4039a3743b1156116bda |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T08:44:15Z |
| publishDate | 2021-03-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-c7f8adf9de2c4039a3743b1156116bda2023-09-02T16:33:50ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942021-03-01971273310.25208/vdv11511083Peculiarities of distribution of HLA class I antigens in patients with lihen planusIrina I. Zakhur0https://orcid.org/0000-0002-1495-4038Sergei V. Koshkin1https://orcid.org/0000-0002-6220-8304Galina A. Zaitseva2Varvara A. Bobro3https://orcid.org/0000-0003-2306-1423Kirov State Medical AcademyKirov State Medical AcademyKirov Research Institute of Hematology and Blood Transfusion FMBAKirov Regional Clinical Skin-Venereologic DispensaryThe article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus. Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the HLA class I. Material and methods. Laboratory analysis of the distribution of HLA class I antigens was carried out in 60 patients with various forms of lichen planus who consider themselves Russian on the basis of linguistic and ethnicity. The duration of the disease is 120 years. Results. When analyzing the typing results in the general group of patients; a tendency to negative association of HLA-A11 and HLA-B7. It was found that the frequency of haplotype combinations A1-B8; A2-B27; A2-B40; A3-B35 significantly exceeded that of healthy people. Analysis of the frequency of phenotypic combinations revealed a significant increase in A3-A19 and B12-B35. Conclusion. Haplotype and phenotypic combinations of HLA A1-B8; A2-B27; A2-B40; A3-B35; A3-A19; B12-B35 are provoking factors in the development of various forms of the disease. The presence of these genetic traits in the individual increases the risk of developing lichen planus by 311 times. In turn; the HLA-A11 and B7 antigens play a protective role.https://vestnikdv.ru/jour/article/viewFile/1151/1163lichen planusimmunogenetic indicatorsantigens of the hla complex |
| spellingShingle | Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro Peculiarities of distribution of HLA class I antigens in patients with lihen planus Vestnik Dermatologii i Venerologii lichen planus immunogenetic indicators antigens of the hla complex |
| title | Peculiarities of distribution of HLA class I antigens in patients with lihen planus |
| title_full | Peculiarities of distribution of HLA class I antigens in patients with lihen planus |
| title_fullStr | Peculiarities of distribution of HLA class I antigens in patients with lihen planus |
| title_full_unstemmed | Peculiarities of distribution of HLA class I antigens in patients with lihen planus |
| title_short | Peculiarities of distribution of HLA class I antigens in patients with lihen planus |
| title_sort | peculiarities of distribution of hla class i antigens in patients with lihen planus |
| topic | lichen planus immunogenetic indicators antigens of the hla complex |
| url | https://vestnikdv.ru/jour/article/viewFile/1151/1163 |
| work_keys_str_mv | AT irinaizakhur peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT sergeivkoshkin peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT galinaazaitseva peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT varvaraabobro peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus |