Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital
A cross-sectional, analytical study conducted over a period of 6 months from April to September 2021 after the approval of REC on 50 patients with confirmed positive of COVID-19 by SARS-CoV-2 nucleic acid RT-PCR recruited from Isolation departments and intensive care units (ICUs), Beni-Suef Universi...
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| Format: | Article |
| Language: | English |
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Beni-Suef University, Faculty of Medicine
2022-07-01
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| Series: | Egyptian Journal of Medical Research |
| Subjects: | |
| Online Access: | https://ejmr.journals.ekb.eg/article_259009_16f87a7c23d1880122a3383de507b8d9.pdf |
| _version_ | 1828003663352692736 |
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| author | Nada El-Sagheer Azza Gomaa Laila Alsharaway Mervat Abdel-Aziz |
| author_facet | Nada El-Sagheer Azza Gomaa Laila Alsharaway Mervat Abdel-Aziz |
| author_sort | Nada El-Sagheer |
| collection | DOAJ |
| description | A cross-sectional, analytical study conducted over a period of 6 months from April to September 2021 after the approval of REC on 50 patients with confirmed positive of COVID-19 by SARS-CoV-2 nucleic acid RT-PCR recruited from Isolation departments and intensive care units (ICUs), Beni-Suef University hospital. The goal of this study was to assess the serum level of (IL-18) as a biomarker of COVID-19 disease progression. All participants underwent complete blood count (CBC), C- reactive protein (CRP), fibrinogen, D-dimer and liver enzymes and measurement of serum IL- 18 level. All patients had been followed until hospital discharge or death. Forty-two patients (84%) recovered and discharged from the hospital while eight cases (16%) died due to different etiologies: 2 patients due to suppurative lung infection, another 2 because of multi organ failure, 2 patients owing to respiratory failure and alveolar damage, and the last 2 patients with cardiac comorbidity after ischemic heart disease and hypertension.
There were a significant higher level of CRP, D-dimer, ferritin, and IL-18 among died as compared with recovered COVID-19 patients. Platelets count was significantly higher among recovered as compared with died COVID-19 patients. Correlation test showed a significant positive strong linear relationship between CRP level and IL-18, D-dimer level, and IL-18, and between ferritin level and IL-18. High values of IL-18 in patients’ serum helped to assess the poor prognosis which was statistically significant with 81.5% sensitivity and 57.5% specificity at a cutoff point level ≥ 230.75. Elevated serum levels of IL-18 were associated with fatal outcome in the COVID-19 infected patients and showed strong correlation with other inflammatory markers. |
| first_indexed | 2024-04-10T07:02:06Z |
| format | Article |
| id | doaj.art-c7fe194d783b454380226abf61f92cce |
| institution | Directory Open Access Journal |
| issn | 2682-4396 2682-440X |
| language | English |
| last_indexed | 2024-04-10T07:02:06Z |
| publishDate | 2022-07-01 |
| publisher | Beni-Suef University, Faculty of Medicine |
| record_format | Article |
| series | Egyptian Journal of Medical Research |
| spelling | doaj.art-c7fe194d783b454380226abf61f92cce2023-02-27T17:41:50ZengBeni-Suef University, Faculty of MedicineEgyptian Journal of Medical Research2682-43962682-440X2022-07-013319621210.21608/ejmr.2022.259009259009Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University HospitalNada El-Sagheer0Azza Gomaa1Laila Alsharaway2Mervat Abdel-Aziz3Medical Microbiology and Immunology Department, Faculty of Medicine, Nahda University, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Beni-Suef University, EgyptChest Department, Faculty of Medicine, Beni-Suef University, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Beni-Suef University, EgyptA cross-sectional, analytical study conducted over a period of 6 months from April to September 2021 after the approval of REC on 50 patients with confirmed positive of COVID-19 by SARS-CoV-2 nucleic acid RT-PCR recruited from Isolation departments and intensive care units (ICUs), Beni-Suef University hospital. The goal of this study was to assess the serum level of (IL-18) as a biomarker of COVID-19 disease progression. All participants underwent complete blood count (CBC), C- reactive protein (CRP), fibrinogen, D-dimer and liver enzymes and measurement of serum IL- 18 level. All patients had been followed until hospital discharge or death. Forty-two patients (84%) recovered and discharged from the hospital while eight cases (16%) died due to different etiologies: 2 patients due to suppurative lung infection, another 2 because of multi organ failure, 2 patients owing to respiratory failure and alveolar damage, and the last 2 patients with cardiac comorbidity after ischemic heart disease and hypertension. There were a significant higher level of CRP, D-dimer, ferritin, and IL-18 among died as compared with recovered COVID-19 patients. Platelets count was significantly higher among recovered as compared with died COVID-19 patients. Correlation test showed a significant positive strong linear relationship between CRP level and IL-18, D-dimer level, and IL-18, and between ferritin level and IL-18. High values of IL-18 in patients’ serum helped to assess the poor prognosis which was statistically significant with 81.5% sensitivity and 57.5% specificity at a cutoff point level ≥ 230.75. Elevated serum levels of IL-18 were associated with fatal outcome in the COVID-19 infected patients and showed strong correlation with other inflammatory markers.https://ejmr.journals.ekb.eg/article_259009_16f87a7c23d1880122a3383de507b8d9.pdfcovid-19il-18biomarkers |
| spellingShingle | Nada El-Sagheer Azza Gomaa Laila Alsharaway Mervat Abdel-Aziz Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital Egyptian Journal of Medical Research covid-19 il-18 biomarkers |
| title | Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital |
| title_full | Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital |
| title_fullStr | Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital |
| title_full_unstemmed | Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital |
| title_short | Prognostic value of IL18 serum levels in COVID-19 Patients at Beni- Suef University Hospital |
| title_sort | prognostic value of il18 serum levels in covid 19 patients at beni suef university hospital |
| topic | covid-19 il-18 biomarkers |
| url | https://ejmr.journals.ekb.eg/article_259009_16f87a7c23d1880122a3383de507b8d9.pdf |
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