The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin
Abstract Aims Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01183-4 |
| _version_ | 1811329179094876160 |
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| author | Louise Bennet Ayesha Fawad Joachim Struck Sara Lönn Larsson Andreas Bergmann Olle Melander |
| author_facet | Louise Bennet Ayesha Fawad Joachim Struck Sara Lönn Larsson Andreas Bergmann Olle Melander |
| author_sort | Louise Bennet |
| collection | DOAJ |
| description | Abstract Aims Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss. Methods Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months’ duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression. Outcomes Primary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT. Results During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041). Conclusion In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed. Trial registration This study is a secondary analysis of the RCT trial registered at www.clinicaltrials.gov . Registration number: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines. |
| first_indexed | 2024-04-13T15:39:14Z |
| format | Article |
| id | doaj.art-c7fe76d54f87435a8ed0973cd0a2133a |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-13T15:39:14Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-c7fe76d54f87435a8ed0973cd0a2133a2022-12-22T02:41:12ZengBMCBMC Endocrine Disorders1472-68232022-10-0122111010.1186/s12902-022-01183-4The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensinLouise Bennet0Ayesha Fawad1Joachim Struck2Sara Lönn Larsson3Andreas Bergmann4Olle Melander5Department of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversitySphingotec GmbHDepartment of Clinical Sciences, Lund UniversitySphingotec GmbHDepartment of Clinical Sciences, Lund UniversityAbstract Aims Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss. Methods Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months’ duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression. Outcomes Primary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT. Results During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041). Conclusion In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed. Trial registration This study is a secondary analysis of the RCT trial registered at www.clinicaltrials.gov . Registration number: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines.https://doi.org/10.1186/s12902-022-01183-4ProneurotensinCulturally adapted lifestyle interventionWeight lossMiddle EastType 2 diabetesMigration |
| spellingShingle | Louise Bennet Ayesha Fawad Joachim Struck Sara Lönn Larsson Andreas Bergmann Olle Melander The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin BMC Endocrine Disorders Proneurotensin Culturally adapted lifestyle intervention Weight loss Middle East Type 2 diabetes Migration |
| title | The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| title_full | The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| title_fullStr | The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| title_full_unstemmed | The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| title_short | The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| title_sort | effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin |
| topic | Proneurotensin Culturally adapted lifestyle intervention Weight loss Middle East Type 2 diabetes Migration |
| url | https://doi.org/10.1186/s12902-022-01183-4 |
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