Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers
Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes ENO1, ENO2, and ENO3. The altered expression of enolases is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770523000992 |
| _version_ | 1797454380628180992 |
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| author | Jiaojiao Ni Yihui Huang Chaoqun Li Qian Yin Jieer Ying |
| author_facet | Jiaojiao Ni Yihui Huang Chaoqun Li Qian Yin Jieer Ying |
| author_sort | Jiaojiao Ni |
| collection | DOAJ |
| description | Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes ENO1, ENO2, and ENO3. The altered expression of enolases is a common occurrence in various types of cancer. Although most published studies on enolases have predominantly focused on the role of ENO1 in cancer, ENO2 and ENO3 have recently emerged as crucial regulatory molecules in cancer development. Significant progress has been made in understanding their multifaceted roles in oncogenesis. In this comprehensive review, we provide an overview of the structure, subcellular localization, diagnostic and prognostic significance, biological functions, and molecular mechanisms of ENO2 and ENO3 in cancer progression. The importance of enolase in cancer development makes it a novel therapeutic target for clinical applications. Furthermore, we discuss anticancer agents designed to target enolases and summarize their anticancer efficacy in both in vitro and in vivo studies. |
| first_indexed | 2024-03-09T15:36:24Z |
| format | Article |
| id | doaj.art-c7ff07d6b025486c97653f14157d05a6 |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-03-09T15:36:24Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-c7ff07d6b025486c97653f14157d05a62023-11-26T05:13:05ZengElsevierMolecular Therapy: Oncolytics2372-77052023-12-0131100750Beyond ENO1, emerging roles and targeting strategies of other enolases in cancersJiaojiao Ni0Yihui Huang1Chaoqun Li2Qian Yin3Jieer Ying4Department of Hepato-Pancreato-Biliary & Gastric Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, ChinaDepartment of Medical Oncology, The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, ChinaWenzhou Medical University, Wenzhou, Zhejiang 325088, ChinaWenzhou Medical University, Wenzhou, Zhejiang 325088, ChinaDepartment of Hepato-Pancreato-Biliary & Gastric Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310018, China; Corresponding author: Jieer Ying, No. 1, East Banshan Road, Gongshu District, Hangzhou, Zhejiang 310022, China.Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes ENO1, ENO2, and ENO3. The altered expression of enolases is a common occurrence in various types of cancer. Although most published studies on enolases have predominantly focused on the role of ENO1 in cancer, ENO2 and ENO3 have recently emerged as crucial regulatory molecules in cancer development. Significant progress has been made in understanding their multifaceted roles in oncogenesis. In this comprehensive review, we provide an overview of the structure, subcellular localization, diagnostic and prognostic significance, biological functions, and molecular mechanisms of ENO2 and ENO3 in cancer progression. The importance of enolase in cancer development makes it a novel therapeutic target for clinical applications. Furthermore, we discuss anticancer agents designed to target enolases and summarize their anticancer efficacy in both in vitro and in vivo studies.http://www.sciencedirect.com/science/article/pii/S2372770523000992ENO1ENO2ENO3neuron-specific enolasetumor glycolysisbiomarker |
| spellingShingle | Jiaojiao Ni Yihui Huang Chaoqun Li Qian Yin Jieer Ying Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers Molecular Therapy: Oncolytics ENO1 ENO2 ENO3 neuron-specific enolase tumor glycolysis biomarker |
| title | Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers |
| title_full | Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers |
| title_fullStr | Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers |
| title_full_unstemmed | Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers |
| title_short | Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers |
| title_sort | beyond eno1 emerging roles and targeting strategies of other enolases in cancers |
| topic | ENO1 ENO2 ENO3 neuron-specific enolase tumor glycolysis biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2372770523000992 |
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