Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit
Male courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive. Using Drosophila melanogaster, we found that the homolog of mammalian neuropeptide Y, neuropeptide F (NPF), and...
| Những tác giả chính: | , , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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eLife Sciences Publications Ltd
2019-08-01
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| Loạt: | eLife |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://elifesciences.org/articles/49574 |
| _version_ | 1829096917513011200 |
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| author | Weiwei Liu Anindya Ganguly Jia Huang Yijin Wang Jinfei D Ni Adishthi S Gurav Morris A Aguilar Craig Montell |
| author_facet | Weiwei Liu Anindya Ganguly Jia Huang Yijin Wang Jinfei D Ni Adishthi S Gurav Morris A Aguilar Craig Montell |
| author_sort | Weiwei Liu |
| collection | DOAJ |
| description | Male courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive. Using Drosophila melanogaster, we found that the homolog of mammalian neuropeptide Y, neuropeptide F (NPF), and a cluster of male-specific NPF (NPFM) neurons, regulate courtship through affecting courtship drive. Disrupting NPF signaling produces sexually hyperactive males, which are resistant to sexual satiation, and whose courtship is triggered by sub-optimal stimuli. We found that NPFM neurons make synaptic connections with P1 neurons, which comprise the courtship decision center. Activation of P1 neurons elevates NPFM neuronal activity, which then act through NPF receptor neurons to suppress male courtship, and maintain the proper level of male courtship drive. |
| first_indexed | 2024-04-11T09:04:11Z |
| format | Article |
| id | doaj.art-c7ff8290290845d4b51a52625f57d0e3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:11Z |
| publishDate | 2019-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c7ff8290290845d4b51a52625f57d0e32022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2019-08-01810.7554/eLife.49574Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuitWeiwei Liu0https://orcid.org/0000-0001-5082-9114Anindya Ganguly1Jia Huang2https://orcid.org/0000-0001-8336-1562Yijin Wang3https://orcid.org/0000-0001-5488-3089Jinfei D Ni4https://orcid.org/0000-0002-7004-1241Adishthi S Gurav5Morris A Aguilar6Craig Montell7https://orcid.org/0000-0001-5637-1482Department of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesInstitute of Insect Sciences, Zhejiang University, Hangzhou, ChinaDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesDepartment of Molecular, Cellular and Developmental Biology, and the Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United StatesMale courtship is provoked by perception of a potential mate. In addition, the likelihood and intensity of courtship are influenced by recent mating experience, which affects sexual drive. Using Drosophila melanogaster, we found that the homolog of mammalian neuropeptide Y, neuropeptide F (NPF), and a cluster of male-specific NPF (NPFM) neurons, regulate courtship through affecting courtship drive. Disrupting NPF signaling produces sexually hyperactive males, which are resistant to sexual satiation, and whose courtship is triggered by sub-optimal stimuli. We found that NPFM neurons make synaptic connections with P1 neurons, which comprise the courtship decision center. Activation of P1 neurons elevates NPFM neuronal activity, which then act through NPF receptor neurons to suppress male courtship, and maintain the proper level of male courtship drive.https://elifesciences.org/articles/49574courtshipNPFsex drivemalefruitlessbehavior |
| spellingShingle | Weiwei Liu Anindya Ganguly Jia Huang Yijin Wang Jinfei D Ni Adishthi S Gurav Morris A Aguilar Craig Montell Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit eLife courtship NPF sex drive male fruitless behavior |
| title | Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit |
| title_full | Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit |
| title_fullStr | Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit |
| title_full_unstemmed | Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit |
| title_short | Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit |
| title_sort | neuropeptide f regulates courtship in drosophila through a male specific neuronal circuit |
| topic | courtship NPF sex drive male fruitless behavior |
| url | https://elifesciences.org/articles/49574 |
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