A nationwide cohort study on diabetes severity and risk of Parkinson disease
Abstract There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of developing Parkinson’s disease (PD) and share similar dysregulated pathways. We aimed to determine whether the risk of PD increases as diabetes progresses among patients with type 2 DM. Usin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-023-00462-8 |
| _version_ | 1797422731775442944 |
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| author | Kyungdo Han Bongsung Kim Seung Hwan Lee Mee Kyoung Kim |
| author_facet | Kyungdo Han Bongsung Kim Seung Hwan Lee Mee Kyoung Kim |
| author_sort | Kyungdo Han |
| collection | DOAJ |
| description | Abstract There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of developing Parkinson’s disease (PD) and share similar dysregulated pathways. We aimed to determine whether the risk of PD increases as diabetes progresses among patients with type 2 DM. Using a nationally representative database from the Korean National Health Insurance System, 2,362,072 individuals (≥40 years of age) with type 2 DM who underwent regular health checkups during 2009–2012 were followed up until the end of 2018. The diabetes severity score parameters included the number of oral hypoglycemic agents, diabetes duration, insulin use, or presence of chronic kidney disease, diabetic retinopathy, or cardiovascular disease. Each of these characteristics was scored as one unit of diabetes severity and their sum was defined as a diabetes severity score from 0–6. We identified 17,046 incident PD cases during the follow-up. Each component of the diabetes severity score showed a similar intensity for the risk of PD. Compared with subjects with no parameters, HR values (95% confidence intervals) of PD were 1.09 (1.04–1.15) in subjects with one diabetes severity score parameter, 1.28 (1.22–1.35) in subjects with two parameters, 1.55 (1.46–1.65) in subjects with three parameters, 1.96 (1.82–2.11) in subjects with four parameters, 2.08 (1.83–2.36) in subjects with five parameters, and 2.78 (2.05–3.79) in subjects with six parameters. Diabetes severity was associated with an increased risk of developing PD. Severe diabetes may be a risk factor for the development of PD. |
| first_indexed | 2024-03-09T07:37:43Z |
| format | Article |
| id | doaj.art-c8018072d7bd4700a8ded20c827817d3 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T07:37:43Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-c8018072d7bd4700a8ded20c827817d32023-12-03T05:28:38ZengNature Portfolionpj Parkinson's Disease2373-80572023-01-01911810.1038/s41531-023-00462-8A nationwide cohort study on diabetes severity and risk of Parkinson diseaseKyungdo Han0Bongsung Kim1Seung Hwan Lee2Mee Kyoung Kim3Department of Statistics and Actuarial Science, Soongsil UniversityDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of developing Parkinson’s disease (PD) and share similar dysregulated pathways. We aimed to determine whether the risk of PD increases as diabetes progresses among patients with type 2 DM. Using a nationally representative database from the Korean National Health Insurance System, 2,362,072 individuals (≥40 years of age) with type 2 DM who underwent regular health checkups during 2009–2012 were followed up until the end of 2018. The diabetes severity score parameters included the number of oral hypoglycemic agents, diabetes duration, insulin use, or presence of chronic kidney disease, diabetic retinopathy, or cardiovascular disease. Each of these characteristics was scored as one unit of diabetes severity and their sum was defined as a diabetes severity score from 0–6. We identified 17,046 incident PD cases during the follow-up. Each component of the diabetes severity score showed a similar intensity for the risk of PD. Compared with subjects with no parameters, HR values (95% confidence intervals) of PD were 1.09 (1.04–1.15) in subjects with one diabetes severity score parameter, 1.28 (1.22–1.35) in subjects with two parameters, 1.55 (1.46–1.65) in subjects with three parameters, 1.96 (1.82–2.11) in subjects with four parameters, 2.08 (1.83–2.36) in subjects with five parameters, and 2.78 (2.05–3.79) in subjects with six parameters. Diabetes severity was associated with an increased risk of developing PD. Severe diabetes may be a risk factor for the development of PD.https://doi.org/10.1038/s41531-023-00462-8 |
| spellingShingle | Kyungdo Han Bongsung Kim Seung Hwan Lee Mee Kyoung Kim A nationwide cohort study on diabetes severity and risk of Parkinson disease npj Parkinson's Disease |
| title | A nationwide cohort study on diabetes severity and risk of Parkinson disease |
| title_full | A nationwide cohort study on diabetes severity and risk of Parkinson disease |
| title_fullStr | A nationwide cohort study on diabetes severity and risk of Parkinson disease |
| title_full_unstemmed | A nationwide cohort study on diabetes severity and risk of Parkinson disease |
| title_short | A nationwide cohort study on diabetes severity and risk of Parkinson disease |
| title_sort | nationwide cohort study on diabetes severity and risk of parkinson disease |
| url | https://doi.org/10.1038/s41531-023-00462-8 |
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