A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target
Antibodies that can neutralize diverse HIV-1 strains develop in ~10–20% of HIV-1 infected individuals, and their elicitation is a goal of vaccine design. Such antibodies can also serve as therapeutics for those who have already been infected with the virus. Structural characterizations of broadly re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1774 |
| _version_ | 1827681063093141504 |
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| author | Emma Parker Miller Maxwell T. Finkelstein Molly C. Erdman Paul C. Seth Daniela Fera |
| author_facet | Emma Parker Miller Maxwell T. Finkelstein Molly C. Erdman Paul C. Seth Daniela Fera |
| author_sort | Emma Parker Miller |
| collection | DOAJ |
| description | Antibodies that can neutralize diverse HIV-1 strains develop in ~10–20% of HIV-1 infected individuals, and their elicitation is a goal of vaccine design. Such antibodies can also serve as therapeutics for those who have already been infected with the virus. Structural characterizations of broadly reactive antibodies in complex with the HIV-1 spike indicate that there are a limited number of sites of vulnerability on the spike. Analysis of their structures can help reveal commonalities that would be useful in vaccine design and provide insights on combinations of antibodies that can be used to minimize the incidence of viral resistance mutations. In this review, we give an update on recent structures determined of the spike in complex with broadly neutralizing antibodies in the context of all epitopes on the HIV-1 spike identified to date. |
| first_indexed | 2024-03-10T07:09:02Z |
| format | Article |
| id | doaj.art-c802175702db4a77a09afc4ba9502c54 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:09:02Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c802175702db4a77a09afc4ba9502c542023-11-22T15:37:46ZengMDPI AGViruses1999-49152021-09-01139177410.3390/v13091774A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving TargetEmma Parker Miller0Maxwell T. Finkelstein1Molly C. Erdman2Paul C. Seth3Daniela Fera4Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USADepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USADepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USADepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USADepartment of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USAAntibodies that can neutralize diverse HIV-1 strains develop in ~10–20% of HIV-1 infected individuals, and their elicitation is a goal of vaccine design. Such antibodies can also serve as therapeutics for those who have already been infected with the virus. Structural characterizations of broadly reactive antibodies in complex with the HIV-1 spike indicate that there are a limited number of sites of vulnerability on the spike. Analysis of their structures can help reveal commonalities that would be useful in vaccine design and provide insights on combinations of antibodies that can be used to minimize the incidence of viral resistance mutations. In this review, we give an update on recent structures determined of the spike in complex with broadly neutralizing antibodies in the context of all epitopes on the HIV-1 spike identified to date.https://www.mdpi.com/1999-4915/13/9/1774HIV-1envelopespikeneutralizing antibodiesepitopeneutralization |
| spellingShingle | Emma Parker Miller Maxwell T. Finkelstein Molly C. Erdman Paul C. Seth Daniela Fera A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target Viruses HIV-1 envelope spike neutralizing antibodies epitope neutralization |
| title | A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target |
| title_full | A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target |
| title_fullStr | A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target |
| title_full_unstemmed | A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target |
| title_short | A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target |
| title_sort | structural update of neutralizing epitopes on the hiv envelope a moving target |
| topic | HIV-1 envelope spike neutralizing antibodies epitope neutralization |
| url | https://www.mdpi.com/1999-4915/13/9/1774 |
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