Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study
IntroductionEthiopia is the second most populous country in Africa. Ethiopia received most of its COVID-19 vaccines through donations. The Oxford AstraZeneca vaccine is the first to be donated to Ethiopia by the COVAX facility. Healthcare workers were the priority population that received the Oxford...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.937794/full |
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| author | Elias Ali Yesuf Abanoub Riad Abanoub Riad Ahmad Sofi-Mahmudi Ahmad Sofi-Mahmudi Morankar Sudhakar Addisalem Mekonnen Selamawit Endalkachew Feyissa Mama Semira Muhidin Bethelhem Ayele Mohammed Yahya Abduselam Usman Jemal Abafita Miloslav Klugar Miloslav Klugar |
| author_facet | Elias Ali Yesuf Abanoub Riad Abanoub Riad Ahmad Sofi-Mahmudi Ahmad Sofi-Mahmudi Morankar Sudhakar Addisalem Mekonnen Selamawit Endalkachew Feyissa Mama Semira Muhidin Bethelhem Ayele Mohammed Yahya Abduselam Usman Jemal Abafita Miloslav Klugar Miloslav Klugar |
| author_sort | Elias Ali Yesuf |
| collection | DOAJ |
| description | IntroductionEthiopia is the second most populous country in Africa. Ethiopia received most of its COVID-19 vaccines through donations. The Oxford AstraZeneca vaccine is the first to be donated to Ethiopia by the COVAX facility. Healthcare workers were the priority population that received the Oxford AstraZeneca COVID-19 vaccine. However, there was no nationwide study on the safety of the vaccine in Ethiopia. This study aimed to measure the prevalence and predictors of self-reported side effects of the Oxford AstraZeneca vaccine.Materials and methodsThe study employed a cross-sectional design. A sample of healthcare workers who took Oxford AstraZeneca COVID-19 vaccine was drawn from four regions of Ethiopia; namely, Amhara, Oromia, Somali, and Southwest. Data were collected on sociodemographic characteristics, medical anamnesis, COVID-19 related anamnesis, and COVID-19 vaccine anamnesis via telephone interview. Descriptive and inferential analyses were done. The software, IBM SPSS Statistics v21.0, was used for analyses of data.ResultsOut of 384 people, 346 responded (response rate: 90.1%). Female accounted for 34.1% of the respondents. The mean age of the respondents was 31.0 years (Standard Deviation (SD) = 7.4). Nurses accounted for 43.7% of the respondents. The prevalence of at least one local- and systemic-side effect was 50.6 and 44.5%, respectively. The most frequent local- and systemic- side effect were injection site pain and headache, respectively. Both types of side effects mostly subsided in the first 3 days. A third of healthcare workers with side effects took at least one medication. Paracetamol followed by diclofenac sodium were taken by healthcare workers to overcome side effects. There was no independent predictor of local side effect. After controlling for age and chronic diseases, the odds of healthcare workers with COVID-19 like symptoms to experience systemic side effects was 1.38 (Confidence Interval (CI): 1.04–1.82) times more than that of healthcare workers without COVID-19 like symptoms.ConclusionsThe prevalence of local- and systemic-side effects of the Oxford AstraZeneca COVID-19 vaccine was modest. As the symptoms were mostly common in the first 3 days, it is preferable to monitor healthcare workers at least in the first 3 days following the administration of the vaccine. |
| first_indexed | 2024-04-13T05:32:27Z |
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| language | English |
| last_indexed | 2024-04-13T05:32:27Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-c80448c695e94afb8ee5a84204b604a52022-12-22T03:00:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-07-011010.3389/fpubh.2022.937794937794Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional studyElias Ali Yesuf0Abanoub Riad1Abanoub Riad2Ahmad Sofi-Mahmudi3Ahmad Sofi-Mahmudi4Morankar Sudhakar5Addisalem Mekonnen6Selamawit Endalkachew7Feyissa Mama8Semira Muhidin9Bethelhem Ayele10Mohammed Yahya11Abduselam Usman12Jemal Abafita13Miloslav Klugar14Miloslav Klugar15Department of Health Policy and Management, Jimma University, Jimma, EthiopiaDepartment of Public Health, Masaryk University, Brno, CzechiaCzech National Center for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Center of Excellence, Masaryk University GRADE Center), Institute of Biostatistics and Analyses, Masaryk University, Brno, CzechiaCochrane Iran Associate Center, National Institute for Medical Research Development, Tehran, IranSeqiz Health Network, Kurdistan University of Medical Sciences, Seqiz, IranDepartment of Health, Behavior and Society, Jimma University, Jimma, EthiopiaJimma University Medical Center, Jimma University, Jimma, EthiopiaDepartment of Pediatrics and Child Health, Jimma University, Jimma, EthiopiaJimma University Medical Center, Jimma University, Jimma, EthiopiaDepartment of Public Health, Woldia University, Woldia, Ethiopia0Gebretsadik Shawo Hospital, Southwest Health Bureau, Bonga, Ethiopia1Jigjiga University Specialized Hospital, Jigjiga University, Jigjiga, Ethiopia2Department of Gynecology and Obstetrics, Jigjiga University, Jigjiga, Ethiopia3Department of Economics, Jimma University, Jimma, EthiopiaCzech National Center for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Center of Excellence, Masaryk University GRADE Center), Institute of Biostatistics and Analyses, Masaryk University, Brno, Czechia4Institute of Health Information and Statistics of the Czech Republic, Prague, CzechiaIntroductionEthiopia is the second most populous country in Africa. Ethiopia received most of its COVID-19 vaccines through donations. The Oxford AstraZeneca vaccine is the first to be donated to Ethiopia by the COVAX facility. Healthcare workers were the priority population that received the Oxford AstraZeneca COVID-19 vaccine. However, there was no nationwide study on the safety of the vaccine in Ethiopia. This study aimed to measure the prevalence and predictors of self-reported side effects of the Oxford AstraZeneca vaccine.Materials and methodsThe study employed a cross-sectional design. A sample of healthcare workers who took Oxford AstraZeneca COVID-19 vaccine was drawn from four regions of Ethiopia; namely, Amhara, Oromia, Somali, and Southwest. Data were collected on sociodemographic characteristics, medical anamnesis, COVID-19 related anamnesis, and COVID-19 vaccine anamnesis via telephone interview. Descriptive and inferential analyses were done. The software, IBM SPSS Statistics v21.0, was used for analyses of data.ResultsOut of 384 people, 346 responded (response rate: 90.1%). Female accounted for 34.1% of the respondents. The mean age of the respondents was 31.0 years (Standard Deviation (SD) = 7.4). Nurses accounted for 43.7% of the respondents. The prevalence of at least one local- and systemic-side effect was 50.6 and 44.5%, respectively. The most frequent local- and systemic- side effect were injection site pain and headache, respectively. Both types of side effects mostly subsided in the first 3 days. A third of healthcare workers with side effects took at least one medication. Paracetamol followed by diclofenac sodium were taken by healthcare workers to overcome side effects. There was no independent predictor of local side effect. After controlling for age and chronic diseases, the odds of healthcare workers with COVID-19 like symptoms to experience systemic side effects was 1.38 (Confidence Interval (CI): 1.04–1.82) times more than that of healthcare workers without COVID-19 like symptoms.ConclusionsThe prevalence of local- and systemic-side effects of the Oxford AstraZeneca COVID-19 vaccine was modest. As the symptoms were mostly common in the first 3 days, it is preferable to monitor healthcare workers at least in the first 3 days following the administration of the vaccine.https://www.frontiersin.org/articles/10.3389/fpubh.2022.937794/fullHealthcare workersCOVID-19 vaccineside effectsOxford AstraZenecaEthiopiaAfrica |
| spellingShingle | Elias Ali Yesuf Abanoub Riad Abanoub Riad Ahmad Sofi-Mahmudi Ahmad Sofi-Mahmudi Morankar Sudhakar Addisalem Mekonnen Selamawit Endalkachew Feyissa Mama Semira Muhidin Bethelhem Ayele Mohammed Yahya Abduselam Usman Jemal Abafita Miloslav Klugar Miloslav Klugar Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study Frontiers in Public Health Healthcare workers COVID-19 vaccine side effects Oxford AstraZeneca Ethiopia Africa |
| title | Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study |
| title_full | Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study |
| title_fullStr | Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study |
| title_full_unstemmed | Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study |
| title_short | Self-reported side effects of the Oxford AstraZeneca COVID-19 vaccine among healthcare workers in Ethiopia, Africa: A cross-sectional study |
| title_sort | self reported side effects of the oxford astrazeneca covid 19 vaccine among healthcare workers in ethiopia africa a cross sectional study |
| topic | Healthcare workers COVID-19 vaccine side effects Oxford AstraZeneca Ethiopia Africa |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.937794/full |
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