Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia

Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia

IntroductionThe pandemic coronavirus disease 19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is marked by thromboembolic events and an inflammatory response throughout the body, including the brainMethodsEmploying the machine learning approach BrainDead we...

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Bibliographic Details
Main Authors: Thomas Wallach, Martin Raden, Lukas Hinkelmann, Mariam Brehm, Dominik Rabsch, Hannah Weidling, Christina Krüger, Helmut Kettenmann, Rolf Backofen, Seija Lehnardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
RNA
toll-like receptors
iPSC-derived human microglia
macrophages
inflammatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066456/full

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