Calycosin attenuates renal ischemia/reperfusion injury by suppressing NF-κB mediated inflammation via PPARγ/EGR1 pathway

Calycosin attenuates renal ischemia/reperfusion injury by suppressing NF-κB mediated inflammation via PPARγ/EGR1 pathway

Renal ischemia reperfusion injury (IRI) is a leading and common cause of acute kidney injury (AKI), and inflammation is a critical factor in ischemic AKI progression. Calycosin (CAL), a major active component of Radix astragali, has been reported to have anti-inflammatory effect in multiple organs....

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Bibliographic Details
Main Authors: Ningxin Zhang, Chen Guan, Zengying Liu, Chenyu Li, Chengyu Yang, Lingyu Xu, Meng Niu, Long Zhao, Bin Zhou, Lin Che, Yanfei Wang, Yan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
calycosin
acute kidney injury
ischemia/reperfusion injury
peroxisome proliferator-activated receptor γ
early growth response 1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.970616/full

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