HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction

HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction

Preeclampsia is associated with first trimester placental dysfunction. miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. The effects of elevated miR-210 on placental function remain unclear. The objectives of this study were to identify targets of miR-210 in first trimester...

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Bibliographic Details
Main Authors: Lauren Anton, Ann DeVine, Erzsebet Polyak, Anthony Olarerin-George, Amy G. Brown, Marni J. Falk, Michal A. Elovitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Physiology
Subjects:
preeclampsia
extravillous trophoblast
miRNA
miR-210
mitochondrial respiration
ISCU
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00699/full

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