SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex

SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex

Abstract Background SALL1 is a multi-zinc finger transcription factor that regulates organogenesis and stem cell development, but the role of SALL1 in tumor biology and tumorigenesis remains largely unknown. Methods We analyzed SALL1 expression levels in human and murine breast cancer cells as well...

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Bibliographic Details
Main Authors: Chunling Ma, Fang Wang, Bing Han, Xiaoli Zhong, Fusheng Si, Jian Ye, Eddy C. Hsueh, Lynn Robbins, Susan M. Kiefer, Yanping Zhang, Pamela Hunborg, Mark A. Varvares, Michael Rauchman, Guangyong Peng
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Molecular Cancer
Subjects:
SALL1
Tumor suppressor gene
Senescence
NuRD complex
Tumorigenesis
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12943-018-0824-y

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http://link.springer.com/article/10.1186/s12943-018-0824-y

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