Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up
Background: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. Objectives: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. Methods: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867023000673 |
| _version_ | 1827798989132529664 |
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| author | Érico C. Cardoso-Neto Eduardo Martins Netto Carlos Brites |
| author_facet | Érico C. Cardoso-Neto Eduardo Martins Netto Carlos Brites |
| author_sort | Érico C. Cardoso-Neto |
| collection | DOAJ |
| description | Background: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. Objectives: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. Methods: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3). Data on CD4 count, HIV viral load, weight/Body Mass Index (BMI), lipids and glucose levels were collected at baseline, 24 and 48 weeks of treatment. For analysis purpose, patients were categorized according to their BMI progression. Results: A total of 270 patients were included in the study. Mean CD4 count were 78.3 ± 61.7 and 536.7 ± 273 cells/mm3 for low and high CD4 count groups, respectively (p < 0.001). Baseline BMI was significantly lower in low CD4 group (21.7 vs. 23.6 Kg/m2, p < 0.001). Patients in low CD4 group gained more weight than those in high CD4 group (11.2 ± 8.5 kg vs. 2.2 ± 4.2 Kg, p = 0.004). Overall weight gain was higher in women, regardless group (13.1 ± 7.9 Kg vs. 1.4 ± 3.6 Kg for women and men, respectively, p < 0.001). The proportion of overweight/obesity significantly increased in low CD4 group. Viral suppression rate was high for both groups. At week 48 the overall proportion of overweight/obesity was like that reported for the Brazilian population. Conclusions: Weight gain in the present study indicates a “return to health” phenomenon. Excessive weight gain was more frequent in women. |
| first_indexed | 2024-03-11T19:43:52Z |
| format | Article |
| id | doaj.art-c806f59625a749c5812d3147fee5968e |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-03-11T19:43:52Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-c806f59625a749c5812d3147fee5968e2023-10-06T04:44:12ZengElsevierBrazilian Journal of Infectious Diseases1413-86702023-09-01275102807Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow upÉrico C. Cardoso-Neto0Eduardo Martins Netto1Carlos Brites2Faculdade de Medicina da Universidade Federal da Bahia, Salvador, BA, BrazilFaculdade de Medicina da Universidade Federal da Bahia, Salvador, BA, BrazilFaculdade de Medicina da Universidade Federal da Bahia, Salvador, BA, Brazil; Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil; Corresponding author.Background: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. Objectives: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. Methods: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3). Data on CD4 count, HIV viral load, weight/Body Mass Index (BMI), lipids and glucose levels were collected at baseline, 24 and 48 weeks of treatment. For analysis purpose, patients were categorized according to their BMI progression. Results: A total of 270 patients were included in the study. Mean CD4 count were 78.3 ± 61.7 and 536.7 ± 273 cells/mm3 for low and high CD4 count groups, respectively (p < 0.001). Baseline BMI was significantly lower in low CD4 group (21.7 vs. 23.6 Kg/m2, p < 0.001). Patients in low CD4 group gained more weight than those in high CD4 group (11.2 ± 8.5 kg vs. 2.2 ± 4.2 Kg, p = 0.004). Overall weight gain was higher in women, regardless group (13.1 ± 7.9 Kg vs. 1.4 ± 3.6 Kg for women and men, respectively, p < 0.001). The proportion of overweight/obesity significantly increased in low CD4 group. Viral suppression rate was high for both groups. At week 48 the overall proportion of overweight/obesity was like that reported for the Brazilian population. Conclusions: Weight gain in the present study indicates a “return to health” phenomenon. Excessive weight gain was more frequent in women.http://www.sciencedirect.com/science/article/pii/S1413867023000673DolutegravirWeight gainCD4Obesity |
| spellingShingle | Érico C. Cardoso-Neto Eduardo Martins Netto Carlos Brites Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up Brazilian Journal of Infectious Diseases Dolutegravir Weight gain CD4 Obesity |
| title | Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up |
| title_full | Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up |
| title_fullStr | Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up |
| title_full_unstemmed | Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up |
| title_short | Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up |
| title_sort | weight gain in patients starting dolutegravir based art according to baseline cd4 count after 48 weeks of follow up |
| topic | Dolutegravir Weight gain CD4 Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S1413867023000673 |
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