Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus
The outbreak of a novel strain coronavirus as the causative agent of COVID-19 pneumonia, first identified in Wuhan, China in December 2019, has resulted in considerable focus on virulence abilities of coronavirus. Lectins are natural proteins with the ability to bind specific carbohydrates related t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/12/580 |
| _version_ | 1797545473961099264 |
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| author | Mehran Alavi Kofi Asare-Addo Ali Nokhodchi |
| author_facet | Mehran Alavi Kofi Asare-Addo Ali Nokhodchi |
| author_sort | Mehran Alavi |
| collection | DOAJ |
| description | The outbreak of a novel strain coronavirus as the causative agent of COVID-19 pneumonia, first identified in Wuhan, China in December 2019, has resulted in considerable focus on virulence abilities of coronavirus. Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. In this mini-review, recent advances and challenges related to important lectins with inhibition activities against coronaviruses are presented to obtain a novel viewpoint of microformulations or nanoformulations by micellar and liposomal cell-binding carriers. |
| first_indexed | 2024-03-10T14:16:56Z |
| format | Article |
| id | doaj.art-c8088faf105b4979869a888c65535fe8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:16:56Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c8088faf105b4979869a888c65535fe82023-11-20T23:46:03ZengMDPI AGBiomedicines2227-90592020-12-0181258010.3390/biomedicines8120580Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against CoronavirusMehran Alavi0Kofi Asare-Addo1Ali Nokhodchi2Nanobiotechnology Laboratory, Faculty of Science, Razi University, Kermanshah 67146, IranDepartment of Pharmacy, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UKPharmaceuics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UKThe outbreak of a novel strain coronavirus as the causative agent of COVID-19 pneumonia, first identified in Wuhan, China in December 2019, has resulted in considerable focus on virulence abilities of coronavirus. Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. In this mini-review, recent advances and challenges related to important lectins with inhibition activities against coronaviruses are presented to obtain a novel viewpoint of microformulations or nanoformulations by micellar and liposomal cell-binding carriers.https://www.mdpi.com/2227-9059/8/12/580coronavirusesCOVID-19 pneumonialectinsnanoformulationsmicellesliposomes |
| spellingShingle | Mehran Alavi Kofi Asare-Addo Ali Nokhodchi Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus Biomedicines coronaviruses COVID-19 pneumonia lectins nanoformulations micelles liposomes |
| title | Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus |
| title_full | Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus |
| title_fullStr | Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus |
| title_full_unstemmed | Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus |
| title_short | Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus |
| title_sort | lectin protein as a promising component to functionalize micelles liposomes and lipid nps against coronavirus |
| topic | coronaviruses COVID-19 pneumonia lectins nanoformulations micelles liposomes |
| url | https://www.mdpi.com/2227-9059/8/12/580 |
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