Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains
Hydroxide [Ag(OH)L] (L = <sup>IV</sup>L, <sup>V</sup>L, <sup>VI</sup>L, <sup>VII</sup>L), oxide [{AgL}<sub>2</sub>}(μ-O)] (L = <sup>I</sup>L, <sup>II</sup>L, <sup>III</sup>L, <sup>V</sup...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/3/144 |
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| author | Joana P. Costa M. Joana F. Pinheiro Sílvia A. Sousa Ana M. Botelho do Rego Fernanda Marques M. Conceição Oliveira Jorge H. Leitão Nuno P. Mira M. Fernanda N. N. Carvalho |
| author_facet | Joana P. Costa M. Joana F. Pinheiro Sílvia A. Sousa Ana M. Botelho do Rego Fernanda Marques M. Conceição Oliveira Jorge H. Leitão Nuno P. Mira M. Fernanda N. N. Carvalho |
| author_sort | Joana P. Costa |
| collection | DOAJ |
| description | Hydroxide [Ag(OH)L] (L = <sup>IV</sup>L, <sup>V</sup>L, <sup>VI</sup>L, <sup>VII</sup>L), oxide [{AgL}<sub>2</sub>}(μ-O)] (L = <sup>I</sup>L, <sup>II</sup>L, <sup>III</sup>L, <sup>V</sup>L, <sup>VI</sup>L) or chloride [Ag<sup>II</sup>L]Cl, [Ag(<sup>VI</sup>L)<sub>2</sub>]Cl complexes were obtained from reactions of mono- or bicamphorimine derivatives with Ag(OAc) or AgCl. The new complexes were characterized by spectroscopic (NMR, FTIR) and elemental analysis. X-ray photoelectron spectroscopy (XPS), ESI mass spectra and conductivity measurements were undertaken to corroborate formulations. The antimicrobial activity of complexes and some ligands were evaluated towards <i>Candida albicans</i> and <i>Candida glabrata</i>, and strains of the bacterial species <i>Escherichia coli</i>, <i>Burkholderia contaminans</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> based on the Minimum Inhibitory Concentrations (MIC). Complexes displayed very high activity against the <i>Candida</i> species studied with the lowest MIC values (3.9 µg/mL) being observed for complexes <b>9</b> and <b>10A</b> against <i>C. albicans</i>. A significant feature of these redesigned complexes is their ability to sensitize <i>C. albicans</i>, a trait that was not found for the previously investigated [Ag(NO<sub>3</sub>)L] complexes. The MIC values of the complexes towards bacteria were in the range of those of [Ag(NO<sub>3</sub>)L] and well above those of the precursors Ag(OAc) or AgCl. The activity of the complexes towards normal fibroblasts V79 was evaluated by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Results showed that the complexes have a significant cytotoxicity. |
| first_indexed | 2024-04-13T03:23:06Z |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-13T03:23:06Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj.art-c80927bad0bb431cb39bf334a0f684fe2022-12-22T03:04:44ZengMDPI AGAntibiotics2079-63822019-09-018314410.3390/antibiotics8030144antibiotics8030144Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> StrainsJoana P. Costa0M. Joana F. Pinheiro1Sílvia A. Sousa2Ana M. Botelho do Rego3Fernanda Marques4M. Conceição Oliveira5Jorge H. Leitão6Nuno P. Mira7M. Fernanda N. N. Carvalho8Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalInstituto de Bioengenharia e Biociências, Departamento de Bioengenharia, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalCentro de Química-Física Molecular e BSIRG, Instituto de Bioengenharia e Biociências, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalC2TN Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, PortugalCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalInstituto de Bioengenharia e Biociências, Departamento de Bioengenharia, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalInstituto de Bioengenharia e Biociências, Departamento de Bioengenharia, Instituto Superior Técnico Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalHydroxide [Ag(OH)L] (L = <sup>IV</sup>L, <sup>V</sup>L, <sup>VI</sup>L, <sup>VII</sup>L), oxide [{AgL}<sub>2</sub>}(μ-O)] (L = <sup>I</sup>L, <sup>II</sup>L, <sup>III</sup>L, <sup>V</sup>L, <sup>VI</sup>L) or chloride [Ag<sup>II</sup>L]Cl, [Ag(<sup>VI</sup>L)<sub>2</sub>]Cl complexes were obtained from reactions of mono- or bicamphorimine derivatives with Ag(OAc) or AgCl. The new complexes were characterized by spectroscopic (NMR, FTIR) and elemental analysis. X-ray photoelectron spectroscopy (XPS), ESI mass spectra and conductivity measurements were undertaken to corroborate formulations. The antimicrobial activity of complexes and some ligands were evaluated towards <i>Candida albicans</i> and <i>Candida glabrata</i>, and strains of the bacterial species <i>Escherichia coli</i>, <i>Burkholderia contaminans</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> based on the Minimum Inhibitory Concentrations (MIC). Complexes displayed very high activity against the <i>Candida</i> species studied with the lowest MIC values (3.9 µg/mL) being observed for complexes <b>9</b> and <b>10A</b> against <i>C. albicans</i>. A significant feature of these redesigned complexes is their ability to sensitize <i>C. albicans</i>, a trait that was not found for the previously investigated [Ag(NO<sub>3</sub>)L] complexes. The MIC values of the complexes towards bacteria were in the range of those of [Ag(NO<sub>3</sub>)L] and well above those of the precursors Ag(OAc) or AgCl. The activity of the complexes towards normal fibroblasts V79 was evaluated by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Results showed that the complexes have a significant cytotoxicity.https://www.mdpi.com/2079-6382/8/3/144silver complexescamphorimineanti-<i>Candida</i> activityantifungalsantibacterials |
| spellingShingle | Joana P. Costa M. Joana F. Pinheiro Sílvia A. Sousa Ana M. Botelho do Rego Fernanda Marques M. Conceição Oliveira Jorge H. Leitão Nuno P. Mira M. Fernanda N. N. Carvalho Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains Antibiotics silver complexes camphorimine anti-<i>Candida</i> activity antifungals antibacterials |
| title | Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains |
| title_full | Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains |
| title_fullStr | Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains |
| title_full_unstemmed | Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains |
| title_short | Antimicrobial Activity of Silver Camphorimine Complexes against <i>Candida</i> Strains |
| title_sort | antimicrobial activity of silver camphorimine complexes against i candida i strains |
| topic | silver complexes camphorimine anti-<i>Candida</i> activity antifungals antibacterials |
| url | https://www.mdpi.com/2079-6382/8/3/144 |
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