Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Compound-3 is an oral monophosphate prodrug of gemcitabine. Previous data showed that Compound-3 was more potent than gemcitabine and it was orally active in a tumor xenograft model. In the present study, the metabolism of Compound-3 was investigated in several well-known in vitro matrices. While re...

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Bibliographic Details
Main Authors: Yedong Wang, Yuan Li, Jia Lu, Huixin Qi, Isabel Cheng, Hongjian Zhang
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
gemcitabine
monophosphate prodrug
in vitro metabolism
CYP4F2
drug interactions
Online Access:http://www.mdpi.com/1420-3049/23/5/1195

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