Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women
IntroductionThere are insufficient epidemiological studies on the impact of age at first sexual intercourse (AFS) and age at first live birth (AFB) on postpartum depression (PPD) in pregnant women, and the conclusions of these studies are inconsistent.MethodsWe performed a Mendelian randomization (M...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1287934/full |
| _version_ | 1797219276952698880 |
|---|---|
| author | Xuemin Zhao Linfei Liu |
| author_facet | Xuemin Zhao Linfei Liu |
| author_sort | Xuemin Zhao |
| collection | DOAJ |
| description | IntroductionThere are insufficient epidemiological studies on the impact of age at first sexual intercourse (AFS) and age at first live birth (AFB) on postpartum depression (PPD) in pregnant women, and the conclusions of these studies are inconsistent.MethodsWe performed a Mendelian randomization (MR) study to determine the causal relationship between AFS or AFB and the risk of PPD. The summary data were extracted from genome-wide association study (GWAS) summary datasets. We selected the instrumental variables according to the P value of exposure-related single nucleotide polymorphisms (P<5 ×10-9 for AFS and P<5 ×10-8 for AFB) and estimated the linkage disequilibrium using the clump parameter (10,000 kb, r2 < 0.001). Single nucleotide polymorphisms were considered instrumental variables that were significantly associated with exposure factors without linkage disequilibrium. The F-statistics of the instrumental variables should all be larger than 10. A random-effects model of IVW was constructed as the main method in our study.Results and discussionMR studies based on GWAS data revealed that both AFS (OR = 0.4, P <0.001) and AFB (OR = 0.38, P <0.001) were negatively correlated with the risk of PPD. Early AFS and early AFB should be studied as possible risk factors for PPD in the future. Public health departments should attach importance to sex education for young girls. The results of our TSMR should be verified by high-quality prospective epidemiological studies in the future. |
| first_indexed | 2024-04-24T12:31:05Z |
| format | Article |
| id | doaj.art-c80da199bd614d8280eb6e9354b57f03 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-24T12:31:05Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c80da199bd614d8280eb6e9354b57f032024-04-08T04:42:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-04-011510.3389/fpsyt.2024.12879341287934Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant womenXuemin Zhao0Linfei Liu1Department of Internal Medicine, Chengde Medical University, Chengde, ChinaSericultural Research Institute, Chengde Medical University, Chengde, ChinaIntroductionThere are insufficient epidemiological studies on the impact of age at first sexual intercourse (AFS) and age at first live birth (AFB) on postpartum depression (PPD) in pregnant women, and the conclusions of these studies are inconsistent.MethodsWe performed a Mendelian randomization (MR) study to determine the causal relationship between AFS or AFB and the risk of PPD. The summary data were extracted from genome-wide association study (GWAS) summary datasets. We selected the instrumental variables according to the P value of exposure-related single nucleotide polymorphisms (P<5 ×10-9 for AFS and P<5 ×10-8 for AFB) and estimated the linkage disequilibrium using the clump parameter (10,000 kb, r2 < 0.001). Single nucleotide polymorphisms were considered instrumental variables that were significantly associated with exposure factors without linkage disequilibrium. The F-statistics of the instrumental variables should all be larger than 10. A random-effects model of IVW was constructed as the main method in our study.Results and discussionMR studies based on GWAS data revealed that both AFS (OR = 0.4, P <0.001) and AFB (OR = 0.38, P <0.001) were negatively correlated with the risk of PPD. Early AFS and early AFB should be studied as possible risk factors for PPD in the future. Public health departments should attach importance to sex education for young girls. The results of our TSMR should be verified by high-quality prospective epidemiological studies in the future.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1287934/fullage at first birthage at first sexual intercoursepostpartum depressioncausal relationshipsex education |
| spellingShingle | Xuemin Zhao Linfei Liu Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women Frontiers in Psychiatry age at first birth age at first sexual intercourse postpartum depression causal relationship sex education |
| title | Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women |
| title_full | Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women |
| title_fullStr | Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women |
| title_full_unstemmed | Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women |
| title_short | Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women |
| title_sort | mendelian randomization analyses for the causal relationship between early age at first sexual intercourse early age at first live birth and postpartum depression in pregnant women |
| topic | age at first birth age at first sexual intercourse postpartum depression causal relationship sex education |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1287934/full |
| work_keys_str_mv | AT xueminzhao mendelianrandomizationanalysesforthecausalrelationshipbetweenearlyageatfirstsexualintercourseearlyageatfirstlivebirthandpostpartumdepressioninpregnantwomen AT linfeiliu mendelianrandomizationanalysesforthecausalrelationshipbetweenearlyageatfirstsexualintercourseearlyageatfirstlivebirthandpostpartumdepressioninpregnantwomen |