Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence
Objective. To evaluate the prognostic factors (clinicalpathological characteristics and treatments) in patients with breast cancer and metastasis to central nervous system (CNS) as the first site of the disease. Materials and methods. Kaplan-Meier method and life tables were used to estimate overall...
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Salud Pública
2018-03-01
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| Series: | Salud Pública de México |
| Subjects: | |
| Online Access: | http://www.saludpublica.mx/index.php/spm/article/view/9082 |
| _version_ | 1818271671743676416 |
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| author | Alejandro Mohar-Betancourt Alberto Alvarado-Miranda Juan Alejandro Torres-Domínguez Paula Cabrera Fernando Lara Medina Yaudim Sadid Villarreal-Gómez Nancy Reynoso-Noverón |
| author_facet | Alejandro Mohar-Betancourt Alberto Alvarado-Miranda Juan Alejandro Torres-Domínguez Paula Cabrera Fernando Lara Medina Yaudim Sadid Villarreal-Gómez Nancy Reynoso-Noverón |
| author_sort | Alejandro Mohar-Betancourt |
| collection | DOAJ |
| description | Objective. To evaluate the prognostic factors (clinicalpathological characteristics and treatments) in patients with breast cancer and metastasis to central nervous system (CNS) as the first site of the disease. Materials and methods. Kaplan-Meier method and life tables were used to estimate overall survival time over a retrospective cohort of 125 breast cancer patients treated at the Instituto Nacional de Cancerología (INCan) during 2007-2015, who presented metastasis to the CNS as the first site of extension of the disease. The cox proportional hazards model was used to determine the prognosis factors. Result. The median overall survival time was 14.2 months (IC95%: 11.83-26.93). Patients with triple negative (TN), according to inmunohistochemistry analysis classification, had lower survival times (p=0.0004) and had a risk of dying two times (p=0.037) higher than patients with a different immunophenotype (HR: 2.77. 95%CI: 1.10-6.99). The degree of intermediate SBR increases the risk of dying in patients with metastasis (HR 2.76, 95% CI: 1.17-6.51). Conclusion. CNS metastasis continues to be a poor prognostic factor that reduces survival and affects quality of life. It is recommended to monitor the early presence of clinical neurological manifestations during follow-up for prompt treatment. TN patients have worse prognosis and HER2+ a better control. |
| first_indexed | 2024-12-12T21:29:53Z |
| format | Article |
| id | doaj.art-c80e5d06386944e6806322e87af914f1 |
| institution | Directory Open Access Journal |
| issn | 0036-3634 1606-7916 |
| language | English |
| last_indexed | 2024-12-12T21:29:53Z |
| publishDate | 2018-03-01 |
| publisher | Instituto Nacional de Salud Pública |
| record_format | Article |
| series | Salud Pública de México |
| spelling | doaj.art-c80e5d06386944e6806322e87af914f12022-12-22T00:11:21ZengInstituto Nacional de Salud PúblicaSalud Pública de México0036-36341606-79162018-03-01602,mar-abr14115010.21149/908216498Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrenceAlejandro Mohar-Betancourt0Alberto Alvarado-Miranda1Juan Alejandro Torres-Domínguez2Paula Cabrera3Fernando Lara Medina4Yaudim Sadid Villarreal-Gómez5Nancy Reynoso-Noverón6Instituto Nacional de Cancerología Instituto de Investigaciones Biomédicas, UNAMInstituto Nacional de CancerologíaInstituto Nacional de CancerologíaInstituto Nacional de CancerologíaInstituto Nacional de CancerologíaInstituto Nacional de CancerologíaInstituto Nacional de CancerologíaObjective. To evaluate the prognostic factors (clinicalpathological characteristics and treatments) in patients with breast cancer and metastasis to central nervous system (CNS) as the first site of the disease. Materials and methods. Kaplan-Meier method and life tables were used to estimate overall survival time over a retrospective cohort of 125 breast cancer patients treated at the Instituto Nacional de Cancerología (INCan) during 2007-2015, who presented metastasis to the CNS as the first site of extension of the disease. The cox proportional hazards model was used to determine the prognosis factors. Result. The median overall survival time was 14.2 months (IC95%: 11.83-26.93). Patients with triple negative (TN), according to inmunohistochemistry analysis classification, had lower survival times (p=0.0004) and had a risk of dying two times (p=0.037) higher than patients with a different immunophenotype (HR: 2.77. 95%CI: 1.10-6.99). The degree of intermediate SBR increases the risk of dying in patients with metastasis (HR 2.76, 95% CI: 1.17-6.51). Conclusion. CNS metastasis continues to be a poor prognostic factor that reduces survival and affects quality of life. It is recommended to monitor the early presence of clinical neurological manifestations during follow-up for prompt treatment. TN patients have worse prognosis and HER2+ a better control.http://www.saludpublica.mx/index.php/spm/article/view/9082metástasis de la neoplasianeoplasias de mamasistema nervioso centralpronóstico |
| spellingShingle | Alejandro Mohar-Betancourt Alberto Alvarado-Miranda Juan Alejandro Torres-Domínguez Paula Cabrera Fernando Lara Medina Yaudim Sadid Villarreal-Gómez Nancy Reynoso-Noverón Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence Salud Pública de México metástasis de la neoplasia neoplasias de mama sistema nervioso central pronóstico |
| title | Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| title_full | Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| title_fullStr | Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| title_full_unstemmed | Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| title_short | Prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| title_sort | prognostic factors in patients with breast cancer and brain metastasis as the first site of recurrence |
| topic | metástasis de la neoplasia neoplasias de mama sistema nervioso central pronóstico |
| url | http://www.saludpublica.mx/index.php/spm/article/view/9082 |
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