A Computational Probe into the Structure and Dynamics of the Full-Length Toll-Like Receptor 3 in a Phospholipid Bilayer

A Computational Probe into the Structure and Dynamics of the Full-Length Toll-Like Receptor 3 in a Phospholipid Bilayer

Toll-like receptor 3 (TLR3) provides the host with antiviral defense by initiating an immune signaling cascade for the production of type I interferons. The X-ray structures of isolated TLR3 ectodomain (ECD) and transmembrane (TM) domains have been reported; however, the structure of a membrane-solv...

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Bibliographic Details
Main Authors: Mahesh Chandra Patra, Maria Batool, Muhammad Haseeb, Sangdun Choi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Toll-like receptor 3
molecular dynamics simulation
phospholipid bilayer
Online Access:https://www.mdpi.com/1422-0067/21/8/2857

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