Epidermal stem cells in wound healing and their clinical applications
Abstract The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-019-1312-z |
| _version_ | 1819297830831915008 |
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| author | Ronghua Yang Fengxia Liu Jingru Wang Xiaodong Chen Julin Xie Kun Xiong |
| author_facet | Ronghua Yang Fengxia Liu Jingru Wang Xiaodong Chen Julin Xie Kun Xiong |
| author_sort | Ronghua Yang |
| collection | DOAJ |
| description | Abstract The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such as burns and diabetes, this process is insufficient to achieve effective treatment. Epidermal stem cells (EPSCs) are a multipotent cell type and are committed to the formation and differentiation of the functional epidermis. As the contributions of EPSCs in wound healing and tissue regeneration have been increasingly attracting the attention of researchers, a rising number of therapies based on EPSCs are currently under development. In this paper, we review the characteristics of EPSCs and the mechanisms underlying their functions during wound healing. Applications of EPSCs are also discussed to determine the potential and feasibility of using EPSCs clinically in wound healing. |
| first_indexed | 2024-12-24T05:20:15Z |
| format | Article |
| id | doaj.art-c816bbd639c6483ea4e6c42010aebca2 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-24T05:20:15Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c816bbd639c6483ea4e6c42010aebca22022-12-21T17:13:29ZengBMCStem Cell Research & Therapy1757-65122019-07-0110111410.1186/s13287-019-1312-zEpidermal stem cells in wound healing and their clinical applicationsRonghua Yang0Fengxia Liu1Jingru Wang2Xiaodong Chen3Julin Xie4Kun Xiong5Department of Burn Surgery, The First People’s Hospital of FoshanDepartment of Human Anatomy, School of Basic Medical Science, Xinjiang Medical UniversityDepartment of Burn Surgery, The First People’s Hospital of FoshanDepartment of Burn Surgery, The First People’s Hospital of FoshanDepartment of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Morphological Sciences Building, Central South UniversityAbstract The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such as burns and diabetes, this process is insufficient to achieve effective treatment. Epidermal stem cells (EPSCs) are a multipotent cell type and are committed to the formation and differentiation of the functional epidermis. As the contributions of EPSCs in wound healing and tissue regeneration have been increasingly attracting the attention of researchers, a rising number of therapies based on EPSCs are currently under development. In this paper, we review the characteristics of EPSCs and the mechanisms underlying their functions during wound healing. Applications of EPSCs are also discussed to determine the potential and feasibility of using EPSCs clinically in wound healing.http://link.springer.com/article/10.1186/s13287-019-1312-zEpidermal stem cellsWound healingSignaling pathwayEpithelial regeneration |
| spellingShingle | Ronghua Yang Fengxia Liu Jingru Wang Xiaodong Chen Julin Xie Kun Xiong Epidermal stem cells in wound healing and their clinical applications Stem Cell Research & Therapy Epidermal stem cells Wound healing Signaling pathway Epithelial regeneration |
| title | Epidermal stem cells in wound healing and their clinical applications |
| title_full | Epidermal stem cells in wound healing and their clinical applications |
| title_fullStr | Epidermal stem cells in wound healing and their clinical applications |
| title_full_unstemmed | Epidermal stem cells in wound healing and their clinical applications |
| title_short | Epidermal stem cells in wound healing and their clinical applications |
| title_sort | epidermal stem cells in wound healing and their clinical applications |
| topic | Epidermal stem cells Wound healing Signaling pathway Epithelial regeneration |
| url | http://link.springer.com/article/10.1186/s13287-019-1312-z |
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