Weak synchronization can alter circadian period length: implications for aging and disease conditions
The synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activities. While our understanding of the circadian cloc...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1242800/full |
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| author | Jihwan Myung Jihwan Myung Jihwan Myung Sungho Hong Christoph Schmal Hélène Vitet Hélène Vitet Hélène Vitet Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu |
| author_facet | Jihwan Myung Jihwan Myung Jihwan Myung Sungho Hong Christoph Schmal Hélène Vitet Hélène Vitet Hélène Vitet Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu |
| author_sort | Jihwan Myung |
| collection | DOAJ |
| description | The synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activities. While our understanding of the circadian clock under synchronization has advanced significantly, less is known about its behavior outside synchronization, which can also fall within a predictable domain. These states not only impact the stability of the rhythms but also modulate the period length. In C57BL/6 mice, aging, diseases, and removal of peripheral circadian oscillators often result in lengthened behavioral circadian periods. Here, we show that these changes can be explained by a surprisingly simple mathematical relationship: the frequency is the reciprocal of the period, and its distribution becomes skewed when the period distribution is symmetric. The synchronized frequency of a population in the skewed distribution and the macroscopic frequency of combined oscillators differ, accounting for some of the atypical circadian period outputs observed in networks without synchronization. Building on this finding, we investigate the dynamics of circadian outputs in the context of aging and disease, where synchronization is weakened. |
| first_indexed | 2024-03-11T21:26:15Z |
| format | Article |
| id | doaj.art-c816f6b9619743ea954e1dc73b2563d8 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T21:26:15Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c816f6b9619743ea954e1dc73b2563d82023-09-28T04:23:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12428001242800Weak synchronization can alter circadian period length: implications for aging and disease conditionsJihwan Myung0Jihwan Myung1Jihwan Myung2Sungho Hong3Christoph Schmal4Hélène Vitet5Hélène Vitet6Hélène Vitet7Mei-Yi Wu8Mei-Yi Wu9Mei-Yi Wu10Mei-Yi Wu11Graduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University, Taipei City, TaiwanBrain and Consciousness Research Centre (BCRC), TMU-Shuang Ho Hospital, New Taipei City, TaiwanComputational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, JapanComputational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, JapanInstitute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, GermanyGraduate Institute of Mind, Brain and Consciousness (GIMBC), Taipei Medical University, Taipei City, TaiwanBrain and Consciousness Research Centre (BCRC), TMU-Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Pediatrics, College of Medicine, National Cheng Kung University, Tainan City, TaiwanDivision of Nephrology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDivision of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanTMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, TaiwanThe synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activities. While our understanding of the circadian clock under synchronization has advanced significantly, less is known about its behavior outside synchronization, which can also fall within a predictable domain. These states not only impact the stability of the rhythms but also modulate the period length. In C57BL/6 mice, aging, diseases, and removal of peripheral circadian oscillators often result in lengthened behavioral circadian periods. Here, we show that these changes can be explained by a surprisingly simple mathematical relationship: the frequency is the reciprocal of the period, and its distribution becomes skewed when the period distribution is symmetric. The synchronized frequency of a population in the skewed distribution and the macroscopic frequency of combined oscillators differ, accounting for some of the atypical circadian period outputs observed in networks without synchronization. Building on this finding, we investigate the dynamics of circadian outputs in the context of aging and disease, where synchronization is weakened.https://www.frontiersin.org/articles/10.3389/fnins.2023.1242800/fullunsynchronized statesperiod-frequency relationcircadian rhythmsfrequency synchronizationKuramoto modelperiod distribution |
| spellingShingle | Jihwan Myung Jihwan Myung Jihwan Myung Sungho Hong Christoph Schmal Hélène Vitet Hélène Vitet Hélène Vitet Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu Mei-Yi Wu Weak synchronization can alter circadian period length: implications for aging and disease conditions Frontiers in Neuroscience unsynchronized states period-frequency relation circadian rhythms frequency synchronization Kuramoto model period distribution |
| title | Weak synchronization can alter circadian period length: implications for aging and disease conditions |
| title_full | Weak synchronization can alter circadian period length: implications for aging and disease conditions |
| title_fullStr | Weak synchronization can alter circadian period length: implications for aging and disease conditions |
| title_full_unstemmed | Weak synchronization can alter circadian period length: implications for aging and disease conditions |
| title_short | Weak synchronization can alter circadian period length: implications for aging and disease conditions |
| title_sort | weak synchronization can alter circadian period length implications for aging and disease conditions |
| topic | unsynchronized states period-frequency relation circadian rhythms frequency synchronization Kuramoto model period distribution |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1242800/full |
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