Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

Heterogeneity in endothelial cell (EC) sub-phenotypes is becoming increasingly appreciated in atherosclerosis progression. Still, studies quantifying EC heterogeneity across whole transcriptomes and epigenomes in both in vitro and in vivo models are lacking. Multiomic profiling concurrently measurin...

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Bibliographic Details
Main Authors: Maria L Adelus, Jiacheng Ding, Binh T Tran, Austin C Conklin, Anna K Golebiewski, Lindsey K Stolze, Michael B Whalen, Darren A Cusanovich, Casey E Romanoski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
endothelial cells
ERG
inflammation
atherosclerosis
vascular biology
epigenetics
Online Access:https://elifesciences.org/articles/91729

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