Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse
Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder characterized by stereotyped behaviors, specific interests, and impaired social and communication skills. Synapses are fundamental structures for transmitting information between neurons. It has been reported t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1096503/full |
| _version_ | 1797855288751030272 |
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| author | Wenhao Zong Wenhao Zong Wenhao Zong Xiaowen Lu Guijun Dong Li Zhang Kefeng Li |
| author_facet | Wenhao Zong Wenhao Zong Wenhao Zong Xiaowen Lu Guijun Dong Li Zhang Kefeng Li |
| author_sort | Wenhao Zong |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder characterized by stereotyped behaviors, specific interests, and impaired social and communication skills. Synapses are fundamental structures for transmitting information between neurons. It has been reported that synaptic deficits, such as the increased or decreased density of synapses, may contribute to the onset of ASD, which affects the synaptic function and neuronal circuits. Therefore, targeting the recovery of the synaptic normal structure and function may be a promising therapeutic strategy to alleviate ASD symptoms. Exercise intervention has been shown to regulate the structural plasticity of synapses and improve ASD symptoms, but the underlying molecular mechanisms require further exploration. In this review, we highlight the characteristics of synaptic structural alterations in the context of ASD and the beneficial effects of an exercise intervention on improving ASD symptoms. Finally, we explore the possible molecular mechanisms of improving ASD symptoms through exercise intervention from the perspective of regulating synaptic structural plasticity, which contributes to further optimizing the related strategies of exercise intervention promoting ASD rehabilitation in future. |
| first_indexed | 2024-04-09T20:21:18Z |
| format | Article |
| id | doaj.art-c818b39ee2f74656aeca676e0a27cfd0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T20:21:18Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c818b39ee2f74656aeca676e0a27cfd02023-03-31T05:28:04ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-03-011410.3389/fpsyt.2023.10965031096503Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapseWenhao Zong0Wenhao Zong1Wenhao Zong2Xiaowen Lu3Guijun Dong4Li Zhang5Kefeng Li6School of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Sports, Quzhou University, Quzhou, ChinaCollege of Sports and Health, Shandong Sport University, Jinan, ChinaDepartment of Sports, Quzhou University, Quzhou, ChinaDepartment of Sports, Quzhou University, Quzhou, ChinaGuangdong-HongKong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, ChinaDepartment of Medicine, Quzhou College of Technology, Quzhou, ChinaAutism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder characterized by stereotyped behaviors, specific interests, and impaired social and communication skills. Synapses are fundamental structures for transmitting information between neurons. It has been reported that synaptic deficits, such as the increased or decreased density of synapses, may contribute to the onset of ASD, which affects the synaptic function and neuronal circuits. Therefore, targeting the recovery of the synaptic normal structure and function may be a promising therapeutic strategy to alleviate ASD symptoms. Exercise intervention has been shown to regulate the structural plasticity of synapses and improve ASD symptoms, but the underlying molecular mechanisms require further exploration. In this review, we highlight the characteristics of synaptic structural alterations in the context of ASD and the beneficial effects of an exercise intervention on improving ASD symptoms. Finally, we explore the possible molecular mechanisms of improving ASD symptoms through exercise intervention from the perspective of regulating synaptic structural plasticity, which contributes to further optimizing the related strategies of exercise intervention promoting ASD rehabilitation in future.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1096503/fullautism spectrum disorderASD symptomsexercise interventionmolecular mechanismssynaptic structural plasticity |
| spellingShingle | Wenhao Zong Wenhao Zong Wenhao Zong Xiaowen Lu Guijun Dong Li Zhang Kefeng Li Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse Frontiers in Psychiatry autism spectrum disorder ASD symptoms exercise intervention molecular mechanisms synaptic structural plasticity |
| title | Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse |
| title_full | Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse |
| title_fullStr | Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse |
| title_full_unstemmed | Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse |
| title_short | Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse |
| title_sort | molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder targeting the structural alterations of synapse |
| topic | autism spectrum disorder ASD symptoms exercise intervention molecular mechanisms synaptic structural plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1096503/full |
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