Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study
Objective:. This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of PCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD). Methods:. In this case-control observational study, four candidate SNPs...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2022-09-01
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| Series: | Journal of Bio-X Research |
| Online Access: | http://journals.lww.com/10.1097/JBR.0000000000000124 |
| _version_ | 1797991571212206080 |
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| author | Xiao Yang Fan Yuan Na Wu Decheng Ren Liangjie Liu Yan Bi Lei Ji Ke Han Mofan Feng Kai Su Fengping Yang Xi Wu Qing Lu Siran Yue Fengyan Jiang Ruirui Wang Guang He Baocheng Liu Xingwang Li Yi Shi |
| author_facet | Xiao Yang Fan Yuan Na Wu Decheng Ren Liangjie Liu Yan Bi Lei Ji Ke Han Mofan Feng Kai Su Fengping Yang Xi Wu Qing Lu Siran Yue Fengyan Jiang Ruirui Wang Guang He Baocheng Liu Xingwang Li Yi Shi |
| author_sort | Xiao Yang |
| collection | DOAJ |
| description | Objective:. This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of PCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD).
Methods:. In this case-control observational study, four candidate SNPs (rs6234, rs155971, rs6232, rs3811951) of PCSK1 were genotyped in 732 NAFLD patients and 823 healthy control participants, all of whom were of ethnic Han Chinese descent. All participants came from Shanghai, China, and joined our study during 2015 to 2016. The frequencies of each allele and genotype, paired linkage disequilibrium, and haplotype were calculated on the SHEsis platform. In addition to SHEsis, five different genetic models (codominant, dominant, recessive, overdominant, and log-additive) were employed to identify the correlation between genotype frequency and NAFLD. This study was approved by the Medical Ethics Committee of Shanghai University of Traditional Chinese Medicine (approved No. 2017LCSY069).
Results:. In a comparison of NAFLD patients and healthy participants, none of the four PCSK1 SNPs were significantly correlated with the occurrence of NAFLD (P > 0.05), in either genotypic or allelic distribution. The recessive model of rs3811951 appeared to show a correlation (odds ratio = 1.077; 95% confidence interval = 0.924–1.256; P = 0.04), but there was no statistical significance after Bonferroni correction (Pcorr > 0.0125).
Conclusions:. Four obesity-related PCSK1 SNPs (rs6234, rs155971, rs6232, rs3811951) showed no significant correlation with the development of NAFLD in a Han Chinese population. |
| first_indexed | 2024-04-11T08:54:26Z |
| format | Article |
| id | doaj.art-c81bc81b31b7474daea9dfd66819d600 |
| institution | Directory Open Access Journal |
| issn | 2096-5672 |
| language | English |
| last_indexed | 2024-04-11T08:54:26Z |
| publishDate | 2022-09-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Journal of Bio-X Research |
| spelling | doaj.art-c81bc81b31b7474daea9dfd66819d6002022-12-22T04:33:20ZengWolters Kluwer HealthJournal of Bio-X Research2096-56722022-09-015312513110.1097/JBR.0000000000000124202209000-00005Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational studyXiao Yang0Fan Yuan1Na Wu2Decheng Ren3Liangjie Liu4Yan Bi5Lei Ji6Ke Han7Mofan Feng8Kai Su9Fengping Yang10Xi Wu11Qing Lu12Siran Yue13Fengyan Jiang14Ruirui Wang15Guang He16Baocheng Liu17Xingwang Li18Yi Shi19a Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universityc Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, Chinac Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, Chinac Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, Chinaa Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universityc Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, Chinaa Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong Universitya Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong UniversityObjective:. This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of PCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD). Methods:. In this case-control observational study, four candidate SNPs (rs6234, rs155971, rs6232, rs3811951) of PCSK1 were genotyped in 732 NAFLD patients and 823 healthy control participants, all of whom were of ethnic Han Chinese descent. All participants came from Shanghai, China, and joined our study during 2015 to 2016. The frequencies of each allele and genotype, paired linkage disequilibrium, and haplotype were calculated on the SHEsis platform. In addition to SHEsis, five different genetic models (codominant, dominant, recessive, overdominant, and log-additive) were employed to identify the correlation between genotype frequency and NAFLD. This study was approved by the Medical Ethics Committee of Shanghai University of Traditional Chinese Medicine (approved No. 2017LCSY069). Results:. In a comparison of NAFLD patients and healthy participants, none of the four PCSK1 SNPs were significantly correlated with the occurrence of NAFLD (P > 0.05), in either genotypic or allelic distribution. The recessive model of rs3811951 appeared to show a correlation (odds ratio = 1.077; 95% confidence interval = 0.924–1.256; P = 0.04), but there was no statistical significance after Bonferroni correction (Pcorr > 0.0125). Conclusions:. Four obesity-related PCSK1 SNPs (rs6234, rs155971, rs6232, rs3811951) showed no significant correlation with the development of NAFLD in a Han Chinese population.http://journals.lww.com/10.1097/JBR.0000000000000124 |
| spellingShingle | Xiao Yang Fan Yuan Na Wu Decheng Ren Liangjie Liu Yan Bi Lei Ji Ke Han Mofan Feng Kai Su Fengping Yang Xi Wu Qing Lu Siran Yue Fengyan Jiang Ruirui Wang Guang He Baocheng Liu Xingwang Li Yi Shi Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study Journal of Bio-X Research |
| title | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study |
| title_full | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study |
| title_fullStr | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study |
| title_full_unstemmed | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study |
| title_short | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population: a case-control observational study |
| title_sort | correlation of pcsk1 with nonalcoholic fatty liver disease in a han chinese population a case control observational study |
| url | http://journals.lww.com/10.1097/JBR.0000000000000124 |
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