Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis
Background: Chinese herbal medicine (CHM) has advantages in treating sequela symptoms of pediatric pneumonia convalescence. Hence, this study aims to evaluate the efficacy and safety of CHM using a meta-analysis approach.Methods: The randomized controlled trials (RCTs) that met the search strategy w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.956736/full |
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| author | Jian-Ning Guo Jian-Ning Guo Xue Bai Xue Bai Hong-Xian Zhang Hong-Xian Zhang Ning Zhang Ning Zhang Jun-Ming Liang Jun-Ming Liang Zi-Yi Guo Zi-Yi Guo Xia Cui |
| author_facet | Jian-Ning Guo Jian-Ning Guo Xue Bai Xue Bai Hong-Xian Zhang Hong-Xian Zhang Ning Zhang Ning Zhang Jun-Ming Liang Jun-Ming Liang Zi-Yi Guo Zi-Yi Guo Xia Cui |
| author_sort | Jian-Ning Guo |
| collection | DOAJ |
| description | Background: Chinese herbal medicine (CHM) has advantages in treating sequela symptoms of pediatric pneumonia convalescence. Hence, this study aims to evaluate the efficacy and safety of CHM using a meta-analysis approach.Methods: The randomized controlled trials (RCTs) that met the search strategy were selected from seven databases from the inception date to December 17, 2021. Based on the Cochrane handbook, the quality of the selected studies was assessed using the risk of bias. Data were expressed as relative risk (RR) or mean difference (MD) and with 95% confidence interval (CI). Subgroup analyses and sensitivity analyses were performed. The Grading Recommendation Assessment, Development, and Evaluation (GRADE) method was used to assess the evidence certainty.Result: Twenty RCTs with 2,241 participants were identified using the search criteria. CHMs included Danshen injection, Liujunzi decoction, Qingfei Tongluo decoction, Yiqi Huoxue decoction, Yupingfeng granule, XiaoErFeiKe granule, Sha-Sheng-Mai-Dong decoction, and so on. Results indicated that CHM combined with Western medicine (WM) or CHM alone improved the total clinical effective rate (RR = 1.22; 95% CI: 1.15–1.29), reduced cough relief time (MD = −2.16; 95% CI: −2.46 to −1.85), lung rales disappearance time (MD = −1.82; 95% CI: −2.17 to −1.47), and length of hospital stay (MD = −2.01, 95% CI: −3.81 to −0.22) in the treatment of pneumonia convalescence in children. However, there was no significant statistical difference regarding the incidence of adverse reactions (RR = 0.57; 95% CI: 0.23–1.43).Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; Identifier CRD42022298936 |
| first_indexed | 2024-04-11T13:27:09Z |
| format | Article |
| id | doaj.art-c81c45326647446eb619b5f2753c7c58 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T13:27:09Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c81c45326647446eb619b5f2753c7c582022-12-22T04:22:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.956736956736Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysisJian-Ning Guo0Jian-Ning Guo1Xue Bai2Xue Bai3Hong-Xian Zhang4Hong-Xian Zhang5Ning Zhang6Ning Zhang7Jun-Ming Liang8Jun-Ming Liang9Zi-Yi Guo10Zi-Yi Guo11Xia Cui12Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaSchool of Graduates, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, ChinaBackground: Chinese herbal medicine (CHM) has advantages in treating sequela symptoms of pediatric pneumonia convalescence. Hence, this study aims to evaluate the efficacy and safety of CHM using a meta-analysis approach.Methods: The randomized controlled trials (RCTs) that met the search strategy were selected from seven databases from the inception date to December 17, 2021. Based on the Cochrane handbook, the quality of the selected studies was assessed using the risk of bias. Data were expressed as relative risk (RR) or mean difference (MD) and with 95% confidence interval (CI). Subgroup analyses and sensitivity analyses were performed. The Grading Recommendation Assessment, Development, and Evaluation (GRADE) method was used to assess the evidence certainty.Result: Twenty RCTs with 2,241 participants were identified using the search criteria. CHMs included Danshen injection, Liujunzi decoction, Qingfei Tongluo decoction, Yiqi Huoxue decoction, Yupingfeng granule, XiaoErFeiKe granule, Sha-Sheng-Mai-Dong decoction, and so on. Results indicated that CHM combined with Western medicine (WM) or CHM alone improved the total clinical effective rate (RR = 1.22; 95% CI: 1.15–1.29), reduced cough relief time (MD = −2.16; 95% CI: −2.46 to −1.85), lung rales disappearance time (MD = −1.82; 95% CI: −2.17 to −1.47), and length of hospital stay (MD = −2.01, 95% CI: −3.81 to −0.22) in the treatment of pneumonia convalescence in children. However, there was no significant statistical difference regarding the incidence of adverse reactions (RR = 0.57; 95% CI: 0.23–1.43).Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; Identifier CRD42022298936https://www.frontiersin.org/articles/10.3389/fphar.2022.956736/fullChinese herbal medicinepneumonia convalescence in childrenmeta-analysissystematic reviewrandomized controlled trials |
| spellingShingle | Jian-Ning Guo Jian-Ning Guo Xue Bai Xue Bai Hong-Xian Zhang Hong-Xian Zhang Ning Zhang Ning Zhang Jun-Ming Liang Jun-Ming Liang Zi-Yi Guo Zi-Yi Guo Xia Cui Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis Frontiers in Pharmacology Chinese herbal medicine pneumonia convalescence in children meta-analysis systematic review randomized controlled trials |
| title | Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis |
| title_full | Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis |
| title_short | Efficacy and safety of Chinese herbal medicine for pneumonia convalescence in children: A systematic review and meta-analysis |
| title_sort | efficacy and safety of chinese herbal medicine for pneumonia convalescence in children a systematic review and meta analysis |
| topic | Chinese herbal medicine pneumonia convalescence in children meta-analysis systematic review randomized controlled trials |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.956736/full |
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