The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review
Selenium is a trace element that provides protection against cellular damage and death. Previous research using several types of cells identified anti-oxidant, anti-inflammatory, and anti-apoptotic effects for selenium. One of the diseases related to selenium is cardiovascular disease, as low seleni...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332220313184 |
| _version_ | 1798033126990020608 |
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| author | Ayu Shalihat Aliya Nur Hasanah Mutakin Ronny Lesmana Arif Budiman Dolih Gozali |
| author_facet | Ayu Shalihat Aliya Nur Hasanah Mutakin Ronny Lesmana Arif Budiman Dolih Gozali |
| author_sort | Ayu Shalihat |
| collection | DOAJ |
| description | Selenium is a trace element that provides protection against cellular damage and death. Previous research using several types of cells identified anti-oxidant, anti-inflammatory, and anti-apoptotic effects for selenium. One of the diseases related to selenium is cardiovascular disease, as low selenium intake has been linked to cardiomyopathy. However, the mechanism of the cardioprotective effects of selenium is not thoroughly understood. Several studies supported the possible effects of selenium on heart cell survival. In this review, we analyzed recent research (2015–2020) on the roles and mechanism of action of selenium in cell survival and its cardioprotective effects. Furthermore, the prevention of apoptosis through both intrinsic and extrinsic pathways is discussed in this review. Signalling pathways that regulate cell survival such as the p-AMPK, poly (ADP-ribose) polymerase-1, nuclear factor-erythroid 2-related factor-2, AKT/PI3K, and STAT pathways are involved in the protective effects of selenium. In addition, signaling pathways that affect heart cell survival include the AKT and STAT pathways. It also affects autophagy through the PPAR-γ pathway. These findings should facilitate further research on the cardioprotective effects of selenium. |
| first_indexed | 2024-04-11T20:25:08Z |
| format | Article |
| id | doaj.art-c81dbbab95254a93abfed67d7386cee8 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T20:25:08Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-c81dbbab95254a93abfed67d7386cee82022-12-22T04:04:41ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-02-01134111125The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature reviewAyu Shalihat0Aliya Nur Hasanah1 Mutakin2Ronny Lesmana3Arif Budiman4Dolih Gozali5Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Departement of Pharmacy, Faculty of Science and Technology, Universitas Muhammadiyah Bandung, Jl. Soekarno - Hatta No. 752, Cipadung Kidul, Panyileukan, Bandung, 40614, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Corresponding author.Physiology Division, Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia; Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, IndonesiaSelenium is a trace element that provides protection against cellular damage and death. Previous research using several types of cells identified anti-oxidant, anti-inflammatory, and anti-apoptotic effects for selenium. One of the diseases related to selenium is cardiovascular disease, as low selenium intake has been linked to cardiomyopathy. However, the mechanism of the cardioprotective effects of selenium is not thoroughly understood. Several studies supported the possible effects of selenium on heart cell survival. In this review, we analyzed recent research (2015–2020) on the roles and mechanism of action of selenium in cell survival and its cardioprotective effects. Furthermore, the prevention of apoptosis through both intrinsic and extrinsic pathways is discussed in this review. Signalling pathways that regulate cell survival such as the p-AMPK, poly (ADP-ribose) polymerase-1, nuclear factor-erythroid 2-related factor-2, AKT/PI3K, and STAT pathways are involved in the protective effects of selenium. In addition, signaling pathways that affect heart cell survival include the AKT and STAT pathways. It also affects autophagy through the PPAR-γ pathway. These findings should facilitate further research on the cardioprotective effects of selenium.http://www.sciencedirect.com/science/article/pii/S0753332220313184SeleniumCardiovascular diseaseCell survivalApoptosis |
| spellingShingle | Ayu Shalihat Aliya Nur Hasanah Mutakin Ronny Lesmana Arif Budiman Dolih Gozali The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review Biomedicine & Pharmacotherapy Selenium Cardiovascular disease Cell survival Apoptosis |
| title | The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review |
| title_full | The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review |
| title_fullStr | The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review |
| title_full_unstemmed | The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review |
| title_short | The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review |
| title_sort | role of selenium in cell survival and its correlation with protective effects against cardiovascular disease a literature review |
| topic | Selenium Cardiovascular disease Cell survival Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332220313184 |
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