Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile
Objectives: To relate the cognitive parameters of systemic lupus erythematosus (SLE) patients in remission to their profile of autoantibodies. Material and methods : The study included 32 patients with SLE in remission, with mild disease activity as indicated by SELENA-SLEDAI < 6. For neurops...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2015-08-01
|
| Series: | Rheumatology |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Original-paper-Cambridge-Neuropsychological-Test-Automated-Battery-in-assessment-of-cognitive-parameters-in-patients-with-systemic-lupus-erythematosus-in-relation-to-autoantibody-profile,18,25549,1,1.html |
| _version_ | 1811217363433947136 |
|---|---|
| author | Anna Bogaczewicz Tomasz Sobow Jan Kowalski Jakub Ząbek Anna Woźniacka Jaroslaw Bogaczewicz |
| author_facet | Anna Bogaczewicz Tomasz Sobow Jan Kowalski Jakub Ząbek Anna Woźniacka Jaroslaw Bogaczewicz |
| author_sort | Anna Bogaczewicz |
| collection | DOAJ |
| description | Objectives: To relate the cognitive parameters of systemic lupus erythematosus (SLE) patients in remission to their profile of autoantibodies.
Material and methods : The study included 32 patients with SLE in remission, with mild disease activity as indicated by SELENA-SLEDAI < 6. For neuropsychological assessment, the Cambridge Neuropsychological Test Automated Battery (CANTAB) was applied, using motor screening (MOT), big little circle (BLC), paired associated learning (PAL), stockings of Cambridge (SOC), and graded naming tests (GNT). Detection of autoantibodies against dsDNA, nucleosome (aNuc), Sm, and anticardiolipin (aCL: IgG and IgM) was performed with immunoassays.
Results: The SLE patients demonstrated standard scores below norms, matched according to age and gender, in the following tests: GNT (–0.87 ±0.85), SOC PSMM (–0.47 ±0.97), PAL (–1.88 ±3.58), and BLC (–0.31 ±1.90). GNT scores under –0.5 were found significantly more frequently in SLE patients, seen in roughly 66% of test subjects. Values for PAL and mean subsequent thinking time of stockings of Cambridge (SOC MSTT) were found to be lower than –0.5 in approximately half of the patients. Mean error of motor screening (MOT ME) was found to negatively correlate with mean latency of motor screening (MOT ML) (r = –0.55). PAL significantly correlated with SOC MSTT (r = 0.38) and with GNT (r = 0.36). Anti-dsDNA antibody level correlated negatively with MOT ME (r = –0.46). Anti-Nuc antibodies correlated with MOT ML (r = 0.41) but negatively correlated with MOT ME
(r = –0.58). The levels of anti-Sm, anti-CL IgM and IgG did not correlate significantly with the outcomes of CANTAB. The age of the patients correlated negatively with MOT ME (r = –0.36), positively with BLC (r = 0.53) and negatively with SOC MSTT (r = –0.43). The level of anti-Nuc antibodies correlated with anti-dsDNA level (r = 0.62) and of anti-CL IgM with anti-Sm (r = 0.39) and anti-CL IgG (r = 0.87).
Conclusions : CANTAB reveals a decrease in selected cognitive functions in patients with SLE. ACL IgG and anti-dsDNA antibodies indicated SLE patients prone to develop a decrease in cognitive functions. |
| first_indexed | 2024-04-12T06:54:10Z |
| format | Article |
| id | doaj.art-c8208e05d69c43b0804bff3111242a06 |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-04-12T06:54:10Z |
| publishDate | 2015-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-c8208e05d69c43b0804bff3111242a062022-12-22T03:43:13ZengTermedia Publishing HouseRheumatology0034-62332084-98342015-08-0153313113810.5114/reum.2015.5313425549Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profileAnna BogaczewiczTomasz SobowJan KowalskiJakub ZąbekAnna WoźniackaJaroslaw BogaczewiczObjectives: To relate the cognitive parameters of systemic lupus erythematosus (SLE) patients in remission to their profile of autoantibodies. Material and methods : The study included 32 patients with SLE in remission, with mild disease activity as indicated by SELENA-SLEDAI < 6. For neuropsychological assessment, the Cambridge Neuropsychological Test Automated Battery (CANTAB) was applied, using motor screening (MOT), big little circle (BLC), paired associated learning (PAL), stockings of Cambridge (SOC), and graded naming tests (GNT). Detection of autoantibodies against dsDNA, nucleosome (aNuc), Sm, and anticardiolipin (aCL: IgG and IgM) was performed with immunoassays. Results: The SLE patients demonstrated standard scores below norms, matched according to age and gender, in the following tests: GNT (–0.87 ±0.85), SOC PSMM (–0.47 ±0.97), PAL (–1.88 ±3.58), and BLC (–0.31 ±1.90). GNT scores under –0.5 were found significantly more frequently in SLE patients, seen in roughly 66% of test subjects. Values for PAL and mean subsequent thinking time of stockings of Cambridge (SOC MSTT) were found to be lower than –0.5 in approximately half of the patients. Mean error of motor screening (MOT ME) was found to negatively correlate with mean latency of motor screening (MOT ML) (r = –0.55). PAL significantly correlated with SOC MSTT (r = 0.38) and with GNT (r = 0.36). Anti-dsDNA antibody level correlated negatively with MOT ME (r = –0.46). Anti-Nuc antibodies correlated with MOT ML (r = 0.41) but negatively correlated with MOT ME (r = –0.58). The levels of anti-Sm, anti-CL IgM and IgG did not correlate significantly with the outcomes of CANTAB. The age of the patients correlated negatively with MOT ME (r = –0.36), positively with BLC (r = 0.53) and negatively with SOC MSTT (r = –0.43). The level of anti-Nuc antibodies correlated with anti-dsDNA level (r = 0.62) and of anti-CL IgM with anti-Sm (r = 0.39) and anti-CL IgG (r = 0.87). Conclusions : CANTAB reveals a decrease in selected cognitive functions in patients with SLE. ACL IgG and anti-dsDNA antibodies indicated SLE patients prone to develop a decrease in cognitive functions.http://www.termedia.pl/Original-paper-Cambridge-Neuropsychological-Test-Automated-Battery-in-assessment-of-cognitive-parameters-in-patients-with-systemic-lupus-erythematosus-in-relation-to-autoantibody-profile,18,25549,1,1.htmlcognitive functions systemic lupus erythematosus neuropsychological test autoantibodies |
| spellingShingle | Anna Bogaczewicz Tomasz Sobow Jan Kowalski Jakub Ząbek Anna Woźniacka Jaroslaw Bogaczewicz Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile Rheumatology cognitive functions systemic lupus erythematosus neuropsychological test autoantibodies |
| title | Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| title_full | Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| title_fullStr | Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| title_full_unstemmed | Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| title_short | Original paper Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| title_sort | original paper cambridge neuropsychological test automated battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile |
| topic | cognitive functions systemic lupus erythematosus neuropsychological test autoantibodies |
| url | http://www.termedia.pl/Original-paper-Cambridge-Neuropsychological-Test-Automated-Battery-in-assessment-of-cognitive-parameters-in-patients-with-systemic-lupus-erythematosus-in-relation-to-autoantibody-profile,18,25549,1,1.html |
| work_keys_str_mv | AT annabogaczewicz originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile AT tomaszsobow originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile AT jankowalski originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile AT jakubzabek originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile AT annawozniacka originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile AT jaroslawbogaczewicz originalpapercambridgeneuropsychologicaltestautomatedbatteryinassessmentofcognitiveparametersinpatientswithsystemiclupuserythematosusinrelationtoautoantibodyprofile |