Investigation of Mir-210 Expression in Breast Cancer Patients
Background and purpose: Breast cancer is one of the most common cancers among women. Abnormal expression of microRNAs is associated with cancer. Therefore, this study aimed to evaluate the expression of miRNA-210 in the serum of breast cancer patients. Materials and methods: The studied population i...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-12-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-20231-en.pdf |
| _version_ | 1797377646251737088 |
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| author | Omolbanin Amjadi Fatemeh Samadi Reza Alizadeh-Navaei Reza Valadan Ehsan Zaboli Najmeh Ahangar Elahe Mahmoodi Akbar Hedayatizadeh-Omran |
| author_facet | Omolbanin Amjadi Fatemeh Samadi Reza Alizadeh-Navaei Reza Valadan Ehsan Zaboli Najmeh Ahangar Elahe Mahmoodi Akbar Hedayatizadeh-Omran |
| author_sort | Omolbanin Amjadi |
| collection | DOAJ |
| description | Background and purpose: Breast cancer is one of the most common cancers among women. Abnormal expression of microRNAs is associated with cancer. Therefore, this study aimed to evaluate the expression of miRNA-210 in the serum of breast cancer patients.
Materials and methods: The studied population included 49 breast cancer patients and 55 healthy individuals, and the samples were evaluated using Real Time PCR.
Results: The data analysis of this study revealed that the expression level of miR-210 in the blood of breast cancer patients is significantly higher compared to the blood of healthy people. Also, there is a negative correlation between the age of breast cancer patients and the expression of miR-210 (r=-0.309, P=0.031) and a significant positive correlation between the increase in the expression of mir-210 and the expression of the Ki-67 marker (r=0.412, P = 0.004). |
| first_indexed | 2024-03-08T19:55:36Z |
| format | Article |
| id | doaj.art-c821746146e84bf0aaaa5a65d421b5ee |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-08T19:55:36Z |
| publishDate | 2023-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-c821746146e84bf0aaaa5a65d421b5ee2023-12-24T06:57:31ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-12-0133227118125Investigation of Mir-210 Expression in Breast Cancer PatientsOmolbanin Amjadi0Fatemeh Samadi1Reza Alizadeh-Navaei2Reza Valadan3Ehsan Zaboli4Najmeh Ahangar5Elahe Mahmoodi6Akbar Hedayatizadeh-Omran7 MSc in Cell and Molecular Biology, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Medical Student, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Cellular and Molecular Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran BSc in Laboratory Science, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran MSc in Statistics, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Breast cancer is one of the most common cancers among women. Abnormal expression of microRNAs is associated with cancer. Therefore, this study aimed to evaluate the expression of miRNA-210 in the serum of breast cancer patients. Materials and methods: The studied population included 49 breast cancer patients and 55 healthy individuals, and the samples were evaluated using Real Time PCR. Results: The data analysis of this study revealed that the expression level of miR-210 in the blood of breast cancer patients is significantly higher compared to the blood of healthy people. Also, there is a negative correlation between the age of breast cancer patients and the expression of miR-210 (r=-0.309, P=0.031) and a significant positive correlation between the increase in the expression of mir-210 and the expression of the Ki-67 marker (r=0.412, P = 0.004).http://jmums.mazums.ac.ir/article-1-20231-en.pdfevaluation of mir-210 can be used as a diagnostic marker in breast cancer |
| spellingShingle | Omolbanin Amjadi Fatemeh Samadi Reza Alizadeh-Navaei Reza Valadan Ehsan Zaboli Najmeh Ahangar Elahe Mahmoodi Akbar Hedayatizadeh-Omran Investigation of Mir-210 Expression in Breast Cancer Patients Journal of Mazandaran University of Medical Sciences evaluation of mir-210 can be used as a diagnostic marker in breast cancer |
| title | Investigation of Mir-210 Expression in Breast Cancer Patients |
| title_full | Investigation of Mir-210 Expression in Breast Cancer Patients |
| title_fullStr | Investigation of Mir-210 Expression in Breast Cancer Patients |
| title_full_unstemmed | Investigation of Mir-210 Expression in Breast Cancer Patients |
| title_short | Investigation of Mir-210 Expression in Breast Cancer Patients |
| title_sort | investigation of mir 210 expression in breast cancer patients |
| topic | evaluation of mir-210 can be used as a diagnostic marker in breast cancer |
| url | http://jmums.mazums.ac.ir/article-1-20231-en.pdf |
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