Allergies and risk of head and neck cancer: an original study plus meta-analysis.
BACKGROUND: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental r...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3562357?pdf=render |
| _version_ | 1818325842474827776 |
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| author | Jenn-Ren Hsiao Chun-Yen Ou Hung-I Lo Cheng-Chih Huang Wei-Ting Lee Jehn-Shyun Huang Ken-Chung Chen Tung-Yiu Wong Sen-Tien Tsai Chia-Jui Yen Yuan-Hua Wu Wei-Ting Hsueh Ming-Wei Yang Shang-Yin Wu Jang-Yang Chang Kwang-Yu Chang Chen-Lin Lin Fang-Ting Wang Yi-Hui Wang Ya-Ling Weng Han-Chien Yang Jeffrey S Chang |
| author_facet | Jenn-Ren Hsiao Chun-Yen Ou Hung-I Lo Cheng-Chih Huang Wei-Ting Lee Jehn-Shyun Huang Ken-Chung Chen Tung-Yiu Wong Sen-Tien Tsai Chia-Jui Yen Yuan-Hua Wu Wei-Ting Hsueh Ming-Wei Yang Shang-Yin Wu Jang-Yang Chang Kwang-Yu Chang Chen-Lin Lin Fang-Ting Wang Yi-Hui Wang Ya-Ling Weng Han-Chien Yang Jeffrey S Chang |
| author_sort | Jenn-Ren Hsiao |
| collection | DOAJ |
| description | BACKGROUND: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. METHODS: THE CURRENT PAPER REPORTS RESULTS FROM: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). RESULTS: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). CONCLUSIONS: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC. |
| first_indexed | 2024-12-13T11:50:54Z |
| format | Article |
| id | doaj.art-c82198df7d694fcfac0ec266cc48cf28 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T11:50:54Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c82198df7d694fcfac0ec266cc48cf282022-12-21T23:47:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5513810.1371/journal.pone.0055138Allergies and risk of head and neck cancer: an original study plus meta-analysis.Jenn-Ren HsiaoChun-Yen OuHung-I LoCheng-Chih HuangWei-Ting LeeJehn-Shyun HuangKen-Chung ChenTung-Yiu WongSen-Tien TsaiChia-Jui YenYuan-Hua WuWei-Ting HsuehMing-Wei YangShang-Yin WuJang-Yang ChangKwang-Yu ChangChen-Lin LinFang-Ting WangYi-Hui WangYa-Ling WengHan-Chien YangJeffrey S ChangBACKGROUND: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. METHODS: THE CURRENT PAPER REPORTS RESULTS FROM: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). RESULTS: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). CONCLUSIONS: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.http://europepmc.org/articles/PMC3562357?pdf=render |
| spellingShingle | Jenn-Ren Hsiao Chun-Yen Ou Hung-I Lo Cheng-Chih Huang Wei-Ting Lee Jehn-Shyun Huang Ken-Chung Chen Tung-Yiu Wong Sen-Tien Tsai Chia-Jui Yen Yuan-Hua Wu Wei-Ting Hsueh Ming-Wei Yang Shang-Yin Wu Jang-Yang Chang Kwang-Yu Chang Chen-Lin Lin Fang-Ting Wang Yi-Hui Wang Ya-Ling Weng Han-Chien Yang Jeffrey S Chang Allergies and risk of head and neck cancer: an original study plus meta-analysis. PLoS ONE |
| title | Allergies and risk of head and neck cancer: an original study plus meta-analysis. |
| title_full | Allergies and risk of head and neck cancer: an original study plus meta-analysis. |
| title_fullStr | Allergies and risk of head and neck cancer: an original study plus meta-analysis. |
| title_full_unstemmed | Allergies and risk of head and neck cancer: an original study plus meta-analysis. |
| title_short | Allergies and risk of head and neck cancer: an original study plus meta-analysis. |
| title_sort | allergies and risk of head and neck cancer an original study plus meta analysis |
| url | http://europepmc.org/articles/PMC3562357?pdf=render |
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