Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania
Sickle cell disease (SCD) is an inherited blood disorder that leads to a variety of complications, including stroke. The use of hydroxyurea (HU) is reported to lessen the frequency and burden of stroke in SCD patients. However, less is known about the prevalence of stroke in SCD patients pre- and du...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2024-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2024/7950925 |
| _version_ | 1827009332275838976 |
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| author | Belinda Nestory Moshi Erick G. Philipo Nancy F. Kileo Joseph Matobo Emili Yondu Dionis Ikunda Daniel Kandonga Koga M. Luhulla Manase Kilonzi |
| author_facet | Belinda Nestory Moshi Erick G. Philipo Nancy F. Kileo Joseph Matobo Emili Yondu Dionis Ikunda Daniel Kandonga Koga M. Luhulla Manase Kilonzi |
| author_sort | Belinda Nestory Moshi |
| collection | DOAJ |
| description | Sickle cell disease (SCD) is an inherited blood disorder that leads to a variety of complications, including stroke. The use of hydroxyurea (HU) is reported to lessen the frequency and burden of stroke in SCD patients. However, less is known about the prevalence of stroke in SCD patients pre- and during the use of HU in sub-Saharan African (SSA) countries. Therefore, the study assessed stroke prevalence before and during uses of hydroxyurea among SCD patients in Tanzania. A hospital-based descriptive cross-sectional study was conducted at the sickle cell clinics in Dar es Salaam, Tanzania, from April 2023 to May 2023. A total of 228 participants were recruited, and data on demographic and clinical characteristics, HU use, and history of stroke were collected using a checklist from the respective patients’ medical records and verbal communication with the patients or caregivers. Data analysis was done using SPSS software version 25, and findings are summarized using frequency and percentages. Out of 228 enrolled SCD patients, 124 (54.4%) were females, 109 (47.8%) were aged between 6 and 12 years, 226 (99.1%) were not married, 181 (79.4%) had primary education, and 209 (95%) were unemployed. The prevalence of stroke pre-HU use was 28 (12.3%) and 6 (2.6%) after starting using HU. Out of 6 with stroke after starting using HU, 3 (50%) had a history of stroke pre-HU uses. The study showed that the prevalence of stroke among SCD patients is significantly reduced after HU use. The findings suggest the need for stakeholders to implement measures to ensure eligible SCD patients are kept on HU. |
| first_indexed | 2024-04-24T18:46:43Z |
| format | Article |
| id | doaj.art-c822c9b26650458189da3371b9bb5b56 |
| institution | Directory Open Access Journal |
| issn | 1687-9112 |
| language | English |
| last_indexed | 2025-02-18T12:46:29Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj.art-c822c9b26650458189da3371b9bb5b562024-11-02T03:59:27ZengHindawi LimitedAdvances in Hematology1687-91122024-01-01202410.1155/2024/7950925Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in TanzaniaBelinda Nestory Moshi0Erick G. Philipo1Nancy F. Kileo2Joseph Matobo3Emili Yondu4Dionis Ikunda5Daniel Kandonga6Koga M. Luhulla7Manase Kilonzi8School of PharmacySchool of PharmacySchool of Diagnostic MedicineDepartment of PediatricsSchool of PharmacySchool of Medicine and DentistrySickle Cell ProgrammeDepartment of PediatricsSchool of PharmacySickle cell disease (SCD) is an inherited blood disorder that leads to a variety of complications, including stroke. The use of hydroxyurea (HU) is reported to lessen the frequency and burden of stroke in SCD patients. However, less is known about the prevalence of stroke in SCD patients pre- and during the use of HU in sub-Saharan African (SSA) countries. Therefore, the study assessed stroke prevalence before and during uses of hydroxyurea among SCD patients in Tanzania. A hospital-based descriptive cross-sectional study was conducted at the sickle cell clinics in Dar es Salaam, Tanzania, from April 2023 to May 2023. A total of 228 participants were recruited, and data on demographic and clinical characteristics, HU use, and history of stroke were collected using a checklist from the respective patients’ medical records and verbal communication with the patients or caregivers. Data analysis was done using SPSS software version 25, and findings are summarized using frequency and percentages. Out of 228 enrolled SCD patients, 124 (54.4%) were females, 109 (47.8%) were aged between 6 and 12 years, 226 (99.1%) were not married, 181 (79.4%) had primary education, and 209 (95%) were unemployed. The prevalence of stroke pre-HU use was 28 (12.3%) and 6 (2.6%) after starting using HU. Out of 6 with stroke after starting using HU, 3 (50%) had a history of stroke pre-HU uses. The study showed that the prevalence of stroke among SCD patients is significantly reduced after HU use. The findings suggest the need for stakeholders to implement measures to ensure eligible SCD patients are kept on HU.http://dx.doi.org/10.1155/2024/7950925 |
| spellingShingle | Belinda Nestory Moshi Erick G. Philipo Nancy F. Kileo Joseph Matobo Emili Yondu Dionis Ikunda Daniel Kandonga Koga M. Luhulla Manase Kilonzi Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania Advances in Hematology |
| title | Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania |
| title_full | Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania |
| title_fullStr | Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania |
| title_full_unstemmed | Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania |
| title_short | Prevalence of Stroke in Individuals with Sickle Cell Disease Pre- and during Hydroxyurea Uses: A Descriptive Cross-Sectional Study in Tanzania |
| title_sort | prevalence of stroke in individuals with sickle cell disease pre and during hydroxyurea uses a descriptive cross sectional study in tanzania |
| url | http://dx.doi.org/10.1155/2024/7950925 |
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