Propofol-Induced Hepatitis
Objectives:To present a rare case of propofol-induced hepatitis. Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. Results: The patient had jaundice, increased transaminases demonstr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2020-10-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/1921 |
| _version_ | 1811327331064610816 |
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| author | Hanna Raisi Thomas Longerich Bernardo Moreira Assuncao Sebastian Mueller Peter Schirmacher Helmut-Karl Seitz |
| author_facet | Hanna Raisi Thomas Longerich Bernardo Moreira Assuncao Sebastian Mueller Peter Schirmacher Helmut-Karl Seitz |
| author_sort | Hanna Raisi |
| collection | DOAJ |
| description | Objectives:To present a rare case of propofol-induced hepatitis.
Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy.
Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition.
Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement. |
| first_indexed | 2024-04-13T15:05:54Z |
| format | Article |
| id | doaj.art-c822cb656d614604bccce9ea6609baf8 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-13T15:05:54Z |
| publishDate | 2020-10-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-c822cb656d614604bccce9ea6609baf82022-12-22T02:42:10ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-10-0110.12890/2020_0019211537Propofol-Induced HepatitisHanna Raisi0Thomas Longerich1Bernardo Moreira Assuncao2Sebastian Mueller3Peter Schirmacher4Helmut-Karl Seitz5Center for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, Heidelberg, GermanyCenter for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, GermanyCenter for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, GermanyInstitute of Pathology, University Hospital Heidelberg, Heidelberg, GermanyCenter for Alcohol Research (CAR), University of Heidelberg and Department of Medicine, Salem Medical Center, Heidelberg, GermanyObjectives:To present a rare case of propofol-induced hepatitis. Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition. Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.https://www.ejcrim.com/index.php/EJCRIM/article/view/1921propofolhepatitisanaesthesia |
| spellingShingle | Hanna Raisi Thomas Longerich Bernardo Moreira Assuncao Sebastian Mueller Peter Schirmacher Helmut-Karl Seitz Propofol-Induced Hepatitis European Journal of Case Reports in Internal Medicine propofol hepatitis anaesthesia |
| title | Propofol-Induced Hepatitis |
| title_full | Propofol-Induced Hepatitis |
| title_fullStr | Propofol-Induced Hepatitis |
| title_full_unstemmed | Propofol-Induced Hepatitis |
| title_short | Propofol-Induced Hepatitis |
| title_sort | propofol induced hepatitis |
| topic | propofol hepatitis anaesthesia |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/1921 |
| work_keys_str_mv | AT hannaraisi propofolinducedhepatitis AT thomaslongerich propofolinducedhepatitis AT bernardomoreiraassuncao propofolinducedhepatitis AT sebastianmueller propofolinducedhepatitis AT peterschirmacher propofolinducedhepatitis AT helmutkarlseitz propofolinducedhepatitis |