Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?
In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00374/full |
| _version_ | 1811306764211060736 |
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| author | Mauricio A. Retamal Mauricio A. Retamal Manuel A. Riquelme Jimmy Stehberg Julio Alcayaga |
| author_facet | Mauricio A. Retamal Mauricio A. Retamal Manuel A. Riquelme Jimmy Stehberg Julio Alcayaga |
| author_sort | Mauricio A. Retamal |
| collection | DOAJ |
| description | In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies. |
| first_indexed | 2024-04-13T08:51:25Z |
| format | Article |
| id | doaj.art-c82432bfa82443b9a645c08c4fa54c4f |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T08:51:25Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-c82432bfa82443b9a645c08c4fa54c4f2022-12-22T02:53:29ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-11-011010.3389/fnmol.2017.00374285784Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?Mauricio A. Retamal0Mauricio A. Retamal1Manuel A. Riquelme2Jimmy Stehberg3Julio Alcayaga4Centro de Fisiología Celular e Integrativa, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Santiago, ChileDepartment of Cell Physiology and Molecular Biophysics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United StatesDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United StatesLaboratorio de Neurobiología, Centro de Investigaciones Biomedicas, Universidad Andres Bello, Santiago, ChileDepartment of Biology, Cell Physiology Center, University of Chile, Santiago, ChileIn this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons. The somas of sensory neurons are located in sensory ganglia (i.e., trigeminal and nodose ganglia). It is well known that within sensory ganglia, sensory neurons do not form neither electrical nor chemical synapses. One of the reasons for this is that each soma is surrounded by glial cells, known as satellite glial cells (SGCs). Recent evidence shows that connexin43 (Cx43) hemichannels and probably pannexons located at SGCs have an important role in paracrine communication between glial cells and sensory neurons. This communication may be exerted via the release of bioactive molecules from SGCs and their subsequent action on receptors located at the soma of sensory neurons. The glio-neuronal communication seems to be relevant for the establishment of chronic pain, hyperalgesia and pathologies associated with tissue inflammation. Based on the current literature, it is possible to propose that Cx43 hemichannels expressed in SGCs could be a novel pharmacological target for treating chronic pain, which need to be directly evaluated in future studies.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00374/fullgap junction channelhemichannelsensory neuronsgliotransmitterssatellite glial cells |
| spellingShingle | Mauricio A. Retamal Mauricio A. Retamal Manuel A. Riquelme Jimmy Stehberg Julio Alcayaga Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? Frontiers in Molecular Neuroscience gap junction channel hemichannel sensory neurons gliotransmitters satellite glial cells |
| title | Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? |
| title_full | Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? |
| title_fullStr | Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? |
| title_full_unstemmed | Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? |
| title_short | Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? |
| title_sort | connexin43 hemichannels in satellite glial cells can they influence sensory neuron activity |
| topic | gap junction channel hemichannel sensory neurons gliotransmitters satellite glial cells |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00374/full |
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