Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension
While the typical patient with idiopathic intracranial hypertension (IIH) is an obese female of childbearing age, there are unique patient populations, such as non-obese females, that have not been well studied. Characterizing this subpopulation may increase awareness our of it, which may prevent un...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/6/1547 |
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| author | Anat Horev Gal Ben-Arie Yair Zlotnik Maor Koltochnik Or Ben Chaim Ron Biederko Tamir Regev Erez Tsumi Ilan Shelef Yana Mechnik Steen Tal Eliav Mark Katson Erel Domany Asaf Honig |
| author_facet | Anat Horev Gal Ben-Arie Yair Zlotnik Maor Koltochnik Or Ben Chaim Ron Biederko Tamir Regev Erez Tsumi Ilan Shelef Yana Mechnik Steen Tal Eliav Mark Katson Erel Domany Asaf Honig |
| author_sort | Anat Horev |
| collection | DOAJ |
| description | While the typical patient with idiopathic intracranial hypertension (IIH) is an obese female of childbearing age, there are unique patient populations, such as non-obese females, that have not been well studied. Characterizing this subpopulation may increase awareness our of it, which may prevent underdiagnosis and improve our understanding of IIH’s underlying pathophysiology. We retrospectively reviewed electronic medical records and compared the clinical and radiological characteristics of non-obese (BMI < 30) and obese (BMI > 30) female patients with IIH. Two hundred and forty-six patients (age 32.3 ± 10) met our inclusion criteria. The non-obese patients (<i>n</i> = 59, 24%) were significantly younger than the obese patients (29.4 ± 9.9 vs. 33.2 ± 10.2, <i>p</i> = 0.004) and had higher rates of severe papilledema (Friesen 4–5; 25.4% vs. 11.8%, <i>p</i> = 0.019), scleral flattening (62.7% vs. 36.9%, <i>p</i> = 0.008), and optic nerve dural ectasia (78.0% vs. 55.6%, <i>p</i> = 0.044). Non-obese patients also had a tendency to have a higher lumbar puncture opening pressure (368 ± 92.7 vs. 344 ± 76.4, <i>p</i> = 0.062). Non-obese patients were three times more likely to present with a combination of scleral flattening and optic nerve dural ectasia (OR = 3.00, CI: 1.57–5.72, χ<sup>2</sup> = 11.63, α < 0.001). Overall, non-obese females with IIH were found to have a more fulminant presentation, typified by higher rates of severe papilledema and radiological findings typical for IIH. |
| first_indexed | 2024-04-24T18:09:34Z |
| format | Article |
| id | doaj.art-c82498f8087a41f2a67e08539745ef5c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T18:09:34Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c82498f8087a41f2a67e08539745ef5c2024-03-27T13:47:40ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136154710.3390/jcm13061547Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial HypertensionAnat Horev0Gal Ben-Arie1Yair Zlotnik2Maor Koltochnik3Or Ben Chaim4Ron Biederko5Tamir Regev6Erez Tsumi7Ilan Shelef8Yana Mechnik Steen9Tal Eliav10Mark Katson11Erel Domany12Asaf Honig13Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Diagnostic Imaging, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelJoyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelJoyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelJoyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Diagnostic Imaging, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelDepartment of Neurology, Rambam Healthcare Campus, Haifa 3109601, IsraelDepartment of Neurology, Rambam Healthcare Campus, Haifa 3109601, IsraelDepartment of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, IsraelWhile the typical patient with idiopathic intracranial hypertension (IIH) is an obese female of childbearing age, there are unique patient populations, such as non-obese females, that have not been well studied. Characterizing this subpopulation may increase awareness our of it, which may prevent underdiagnosis and improve our understanding of IIH’s underlying pathophysiology. We retrospectively reviewed electronic medical records and compared the clinical and radiological characteristics of non-obese (BMI < 30) and obese (BMI > 30) female patients with IIH. Two hundred and forty-six patients (age 32.3 ± 10) met our inclusion criteria. The non-obese patients (<i>n</i> = 59, 24%) were significantly younger than the obese patients (29.4 ± 9.9 vs. 33.2 ± 10.2, <i>p</i> = 0.004) and had higher rates of severe papilledema (Friesen 4–5; 25.4% vs. 11.8%, <i>p</i> = 0.019), scleral flattening (62.7% vs. 36.9%, <i>p</i> = 0.008), and optic nerve dural ectasia (78.0% vs. 55.6%, <i>p</i> = 0.044). Non-obese patients also had a tendency to have a higher lumbar puncture opening pressure (368 ± 92.7 vs. 344 ± 76.4, <i>p</i> = 0.062). Non-obese patients were three times more likely to present with a combination of scleral flattening and optic nerve dural ectasia (OR = 3.00, CI: 1.57–5.72, χ<sup>2</sup> = 11.63, α < 0.001). Overall, non-obese females with IIH were found to have a more fulminant presentation, typified by higher rates of severe papilledema and radiological findings typical for IIH.https://www.mdpi.com/2077-0383/13/6/1547idiopathic intracranial hypertensionobesitysevere papilledemascleral flattening |
| spellingShingle | Anat Horev Gal Ben-Arie Yair Zlotnik Maor Koltochnik Or Ben Chaim Ron Biederko Tamir Regev Erez Tsumi Ilan Shelef Yana Mechnik Steen Tal Eliav Mark Katson Erel Domany Asaf Honig Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension Journal of Clinical Medicine idiopathic intracranial hypertension obesity severe papilledema scleral flattening |
| title | Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension |
| title_full | Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension |
| title_fullStr | Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension |
| title_full_unstemmed | Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension |
| title_short | Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension |
| title_sort | clinical and radiological characteristics of non obese female patients with idiopathic intracranial hypertension |
| topic | idiopathic intracranial hypertension obesity severe papilledema scleral flattening |
| url | https://www.mdpi.com/2077-0383/13/6/1547 |
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