SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity

SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity

Abstract ISG15 is an interferon-stimulated ubiquitin-like protein (UBL) with multifaceted roles as a posttranslational modifier in ISG15 conjugation (ISGylation). However, the mechanistic consequences of ISGylation in cancer have not been fully elucidated, largely due to a lack of knowledge on the I...

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Main Authors: Ji An Kang, Yoon Jung Kim, Kyu Yun Jang, Hye Won Moon, Haeseung Lee, Seonjeong Lee, Hyun Kyu Song, Sang Woo Cho, Yoon Sun Yoo, Hye Gyeong Han, Min-Ju Kim, Myoung Ja Chung, Cheol Yong Choi, Cheolju Lee, Chaeuk Chung, Gang Min Hur, You-Sun Kim, Young Joo Jeon
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01194-2

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