Generation of bivalent chromatin domains during cell fate decisions

Generation of bivalent chromatin domains during cell fate decisions

<p>Abstract</p> <p>Background</p> <p>In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an import...

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Main Authors: De Gobbi Marco, Garrick David, Lynch Magnus, Vernimmen Douglas, Hughes Jim R, Goardon Nicolas, Luc Sidinh, Lower Karen M, Sloane-Stanley Jacqueline A, Pina Cristina, Soneji Shamit, Renella Raffaele, Enver Tariq, Taylor Stephen, Jacobsen Sten Eirik W, Vyas Paresh, Gibbons Richard J, Higgs Douglas R
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Epigenetics & Chromatin
Online Access:http://www.epigeneticsandchromatin.com/content/4/1/9

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