Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways

Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways

Nicotinamide (NAM) is the amide form of niacin and an important precursor of nicotinamide adenine dinucleotide (NAD), which is needed for energy metabolism and cellular functions. Additionally, it has shown neuroprotective properties in several neurodegenerative diseases. Herein, we sought to invest...

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Bibliographic Details
Main Authors:	Inayat Ur Rehman, Amjad Khan, Riaz Ahmad, Kyonghwan Choe, Hyun Young Park, Hyeon Jin Lee, Abubakar Atiq, Jungsung Park, Jong Ryeal Hahm, Myeong Ok Kim
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Biomedicines
Subjects:	nicotinamide (NAM) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneal (i.p) substantia nigra pars compacta (SNpc)
Online Access:	https://www.mdpi.com/2227-9059/10/11/2929

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