Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined el...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/6/866 |
| _version_ | 1797484354395439104 |
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| author | Maria Dimaki Mark Holm Olsen Noemi Rozlosnik Winnie E. Svendsen |
| author_facet | Maria Dimaki Mark Holm Olsen Noemi Rozlosnik Winnie E. Svendsen |
| author_sort | Maria Dimaki |
| collection | DOAJ |
| description | This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub–100 nm particles by a factor of 11 using a flow rate of 2–25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250. |
| first_indexed | 2024-03-09T23:02:19Z |
| format | Article |
| id | doaj.art-c829be20a4894e9b951b248123a78333 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T23:02:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-c829be20a4894e9b951b248123a783332023-11-23T18:00:39ZengMDPI AGMicromachines2072-666X2022-05-0113686610.3390/mi13060866Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic ForcesMaria Dimaki0Mark Holm Olsen1Noemi Rozlosnik2Winnie E. Svendsen3DTU Bioengineering, Technical University of Denmark, Søltofts Plads, Bldg 221, 2800 Kongens Lyngby, DenmarkCenter for Plastics and Packaging Technology, Teknologisk Institut, Gregersensvej 1, 2630 Taastrup, DenmarkEir Diagnostics ApS, Muslingevej 36B, 8250 Egå, DenmarkDTU Bioengineering, Technical University of Denmark, Søltofts Plads, Bldg 221, 2800 Kongens Lyngby, DenmarkThis paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub–100 nm particles by a factor of 11 using a flow rate of 2–25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250.https://www.mdpi.com/2072-666X/13/6/866dielectrophoresisupconcentrationmicrofluidicsnanoparticles |
| spellingShingle | Maria Dimaki Mark Holm Olsen Noemi Rozlosnik Winnie E. Svendsen Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces Micromachines dielectrophoresis upconcentration microfluidics nanoparticles |
| title | Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces |
| title_full | Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces |
| title_fullStr | Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces |
| title_full_unstemmed | Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces |
| title_short | Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces |
| title_sort | sub 100 nm nanoparticle upconcentration in flow by dielectrophoretic forces |
| topic | dielectrophoresis upconcentration microfluidics nanoparticles |
| url | https://www.mdpi.com/2072-666X/13/6/866 |
| work_keys_str_mv | AT mariadimaki sub100nmnanoparticleupconcentrationinflowbydielectrophoreticforces AT markholmolsen sub100nmnanoparticleupconcentrationinflowbydielectrophoreticforces AT noemirozlosnik sub100nmnanoparticleupconcentrationinflowbydielectrophoreticforces AT winnieesvendsen sub100nmnanoparticleupconcentrationinflowbydielectrophoreticforces |