Mesenchymal stem cells and it's Characterization
Although acceptable for cell based therapeutic applications, a rigorous understanding of the Mesenchymal Stem Cells (MSC) requires a better definition of what an MSC is. Inspite of the fact that no unique markers are known for MSCs, many attempts have been made to develop a cell-surface antigen prof...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Veterinary World
2011-01-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.scopemed.org/mnstemps/2/2-1319387108.pdf |
| _version_ | 1818872425040838656 |
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| author | Rajesh Kumar Nitin E Gade Amar Nath Pawan K Dubey M. D. Pratheesh G. Taru Sharma |
| author_facet | Rajesh Kumar Nitin E Gade Amar Nath Pawan K Dubey M. D. Pratheesh G. Taru Sharma |
| author_sort | Rajesh Kumar |
| collection | DOAJ |
| description | Although acceptable for cell based therapeutic applications, a rigorous understanding of the Mesenchymal Stem Cells (MSC) requires a better definition of what an MSC is. Inspite of the fact that no unique markers are known for MSCs, many attempts have been made to develop a cell-surface antigen profile for the better purification and identification of MSCs, particularly important is whether MSCs isolated from different tissues are identifiable by the same immunophenotype. While the precise identity of MSCs remains a challenge, further understanding of their biological properties will be greatly advanced by analyzing the mechanisms that govern their differentiation potential. The ability of MSCs to differentiate into a variety of connective tissue cell types has rendered them an ideal candidate cell source for clinical tissue regeneration strategies. This review focuses specifically in the context of these advances in characterization of adult stem cells via selection of unique cell surface markers and regulation of lineage- specific differentiation of mesenchymal stem cells. [Vet. World 2011; 4(12.000): 571-574] |
| first_indexed | 2024-12-19T12:38:36Z |
| format | Article |
| id | doaj.art-c82a498421334f2db550769bcd70a9f5 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-19T12:38:36Z |
| publishDate | 2011-01-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-c82a498421334f2db550769bcd70a9f52022-12-21T20:21:04ZengVeterinary WorldVeterinary World0972-89882231-09162011-01-01412.000571574Mesenchymal stem cells and it's CharacterizationRajesh KumarNitin E GadeAmar NathPawan K DubeyM. D. PratheeshG. Taru SharmaAlthough acceptable for cell based therapeutic applications, a rigorous understanding of the Mesenchymal Stem Cells (MSC) requires a better definition of what an MSC is. Inspite of the fact that no unique markers are known for MSCs, many attempts have been made to develop a cell-surface antigen profile for the better purification and identification of MSCs, particularly important is whether MSCs isolated from different tissues are identifiable by the same immunophenotype. While the precise identity of MSCs remains a challenge, further understanding of their biological properties will be greatly advanced by analyzing the mechanisms that govern their differentiation potential. The ability of MSCs to differentiate into a variety of connective tissue cell types has rendered them an ideal candidate cell source for clinical tissue regeneration strategies. This review focuses specifically in the context of these advances in characterization of adult stem cells via selection of unique cell surface markers and regulation of lineage- specific differentiation of mesenchymal stem cells. [Vet. World 2011; 4(12.000): 571-574]http://www.scopemed.org/mnstemps/2/2-1319387108.pdfMesenchymal Stem CellsBone MarrowCellular TherapyImmunologic Property |
| spellingShingle | Rajesh Kumar Nitin E Gade Amar Nath Pawan K Dubey M. D. Pratheesh G. Taru Sharma Mesenchymal stem cells and it's Characterization Veterinary World Mesenchymal Stem Cells Bone Marrow Cellular Therapy Immunologic Property |
| title | Mesenchymal stem cells and it's Characterization |
| title_full | Mesenchymal stem cells and it's Characterization |
| title_fullStr | Mesenchymal stem cells and it's Characterization |
| title_full_unstemmed | Mesenchymal stem cells and it's Characterization |
| title_short | Mesenchymal stem cells and it's Characterization |
| title_sort | mesenchymal stem cells and it s characterization |
| topic | Mesenchymal Stem Cells Bone Marrow Cellular Therapy Immunologic Property |
| url | http://www.scopemed.org/mnstemps/2/2-1319387108.pdf |
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