Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells

Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells

Osteoarthritis (OA) affects more than 300 million people worldwide and it is about to become the first disabling disease. OA is characterized by the progressive degradation of the articular cartilage but is a disease of the whole joint. Articular innate immune responses (IIR) associated with tissue...

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Bibliographic Details
Main Authors: Eloi Franco-Trepat, María Guillán-Fresco, Ana Alonso-Pérez, Miriam López-Fagúndez, Andrés Pazos-Pérez, Antia Crespo-Golmar, Oreste Gualillo, Alberto Jorge-Mora, Susana Belén Bravo, Rodolfo Gómez
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
TLR4
IL1
NLRP3
Osteoarthritis
Chondrocytes
Synoviocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222010605

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http://www.sciencedirect.com/science/article/pii/S0753332222010605

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