Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription

Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription

Abstract Background Peritoneal dialysis (PD) remains limited due to dialysis failure caused by peritoneal fibrosis. Tamoxifen (TAM), an inhibitor of estrogen receptor 1 (ESR1), has been reported to treat fibrosis, but the underlying mechanism remains unknown. In this study, we sought to explore whet...

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Bibliographic Details
Main Authors:	Tingting Zhao, Zhengyu Sun, Xueli Lai, Hongtao Lu, Lulu Liu, Shuangxi Li, Ji-hang Yuan, Zhiyong Guo
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Series:	Journal of Translational Medicine
Subjects:	Peritoneal fibrosis Tamoxifen Estrogen receptor 1 Long non-coding RNA H19 Vascular endothelial growth factor A
Online Access:	https://doi.org/10.1186/s12967-023-04470-3

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