Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Background: No-reflow phenomenon after primary percutaneous coronary intervention is a common condition affecting the outcomes; therefore, studying its predictive factors is helpful in identifying patients at high risk. Our objective was to investigate the impact of the total ischemia time on no-ref...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2022-05-01
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| Series: | Anatolian Journal of Cardiology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-55193 |
| _version_ | 1797634185339338752 |
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| author | Mohamed Khalfallah Amany Allaithy Dina Abdelsalam |
| author_facet | Mohamed Khalfallah Amany Allaithy Dina Abdelsalam |
| author_sort | Mohamed Khalfallah |
| collection | DOAJ |
| description | Background: No-reflow phenomenon after primary percutaneous coronary intervention is a common condition affecting the outcomes; therefore, studying its predictive factors is helpful in identifying patients at high risk. Our objective was to investigate the impact of the total ischemia time on no-reflow phenomenon and its correlation to thrombolysis in myocardial infarction flow grade after primary percutaneous coronary intervention.
Methods: This study was conducted on 545 patients with ST-elevation myocardial infarction who underwent PPCI; the patients were divided into two groups according to the incidence of no-reflow, TIMI flow ≤2 was considered no-reflow. The time interval from chest pain onset to balloon dilatation was assessed and correlated to thrombolysis in myocardial infarction flow grade.
Results: The incidence of no-reflow was 13.9%; thrombolysis in myocardial infarction flow ≤2 occurred in 76 patients. Multivariate regression analysis showed that advanced age 65 years, the total ischemia time ˃6 h, high thrombus burden, and cardiogenic shock were the independent predictors of no-reflow phenomenon. Spearman's correlation analysis showed a significant negative correlation between the total ischemia time and thrombolysis in myocardial infarction flow grade (r = −351 and P-value =.001).
Conclusion: The time delay is the main limitation of achieving thrombolysis in myocardial infarction 3 flow after primary percutaneous coronary intervention. The total ischemia time has a significant negative correlation with thrombolysis in myocardial infarction flow grade after primary percutaneous coronary intervention. |
| first_indexed | 2024-03-11T12:05:05Z |
| format | Article |
| id | doaj.art-c82ba52e628744e9a6e7d0df4cc0679a |
| institution | Directory Open Access Journal |
| issn | 2149-2271 |
| language | English |
| last_indexed | 2024-03-11T12:05:05Z |
| publishDate | 2022-05-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-c82ba52e628744e9a6e7d0df4cc0679a2023-11-07T17:43:04ZengKARE PublishingAnatolian Journal of Cardiology2149-22712022-05-0126538238710.5152/AnatolJCardiol.2021.846AJC-55193Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary InterventionMohamed Khalfallah0Amany Allaithy1Dina Abdelsalam2Department of Cardiovascular Medicine, Faculty of Medicine, Tanta University, Tanta, EgyptDepartment of Cardiovascular Medicine, Faculty of Medicine, Tanta University, Tanta, EgyptDepartment of Cardiovascular Medicine, Faculty of Medicine, Tanta University, Tanta, EgyptBackground: No-reflow phenomenon after primary percutaneous coronary intervention is a common condition affecting the outcomes; therefore, studying its predictive factors is helpful in identifying patients at high risk. Our objective was to investigate the impact of the total ischemia time on no-reflow phenomenon and its correlation to thrombolysis in myocardial infarction flow grade after primary percutaneous coronary intervention. Methods: This study was conducted on 545 patients with ST-elevation myocardial infarction who underwent PPCI; the patients were divided into two groups according to the incidence of no-reflow, TIMI flow ≤2 was considered no-reflow. The time interval from chest pain onset to balloon dilatation was assessed and correlated to thrombolysis in myocardial infarction flow grade. Results: The incidence of no-reflow was 13.9%; thrombolysis in myocardial infarction flow ≤2 occurred in 76 patients. Multivariate regression analysis showed that advanced age 65 years, the total ischemia time ˃6 h, high thrombus burden, and cardiogenic shock were the independent predictors of no-reflow phenomenon. Spearman's correlation analysis showed a significant negative correlation between the total ischemia time and thrombolysis in myocardial infarction flow grade (r = −351 and P-value =.001). Conclusion: The time delay is the main limitation of achieving thrombolysis in myocardial infarction 3 flow after primary percutaneous coronary intervention. The total ischemia time has a significant negative correlation with thrombolysis in myocardial infarction flow grade after primary percutaneous coronary intervention.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-55193impactthe total ischemia timeno-reflow phenomenonst-elevation myo-cardial infarctionprimary percutaneous coronary intervention |
| spellingShingle | Mohamed Khalfallah Amany Allaithy Dina Abdelsalam Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Anatolian Journal of Cardiology impact the total ischemia time no-reflow phenomenon st-elevation myo-cardial infarction primary percutaneous coronary intervention |
| title | Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_full | Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_fullStr | Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_full_unstemmed | Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_short | Impact of the Total Ischemia Time on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_sort | impact of the total ischemia time on no reflow phenomenon in patients with st elevation myocardial infarction undergoing primary percutaneous coronary intervention |
| topic | impact the total ischemia time no-reflow phenomenon st-elevation myo-cardial infarction primary percutaneous coronary intervention |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-55193 |
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