Platelet Rich Plasma: Efficacy in Treating Trophic Ulcers in Leprosy
Introduction: Trophic ulcers secondary to leprosy pose a great stigma to the patients and remain a challenge to the treating dermatologists. The discovery of Platelet Rich Plasma (PRP) with its favourable role in wound healing is a boon for the patients. PRP introduces the growth factors directl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8758/21899_CE(RA1)_F(T)_PF1(ROAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Introduction: Trophic ulcers secondary to leprosy pose a great
stigma to the patients and remain a challenge to the treating
dermatologists. The discovery of Platelet Rich Plasma (PRP)
with its favourable role in wound healing is a boon for the
patients. PRP introduces the growth factors directly into the
wound and aids in rapid healing.
Aim: To study the efficacy and safety of PRP in the healing of
trophic ulcers secondary to Hansen’s disease in a tertiary care
centre in Southern India.
Materials and Methods: Based on inclusion and exclusion
criteria, 50 patients were enrolled in the study. PRP was
prepared by manual double spin method. After wound bed
preparation, activated PRP was sprayed over the ulcer and
occlusive dressings were applied. Same procedure was
repeated every week until complete re-epithelisation or up to
six sittings whichever occurred earlier.
Results: In our study, 46 patients (92%) showed complete
healing. In 4 patients (8%), there was marked reduction in wound
size with partial re-epithelization. In 88%, complete healing was
seen after the fourth sitting. Mean time for ulcer healing was
around 4.38 weeks.
Conclusion: PRP therapy leads to faster rate of induction of
granulation tissue with rapid healing. Healing had no direct
statistical correlation with the size, site and duration of ulcer,
the leprosy spectrum and associated motor deformities. It is
a simple, safe and cost effective in-office procedure, albeit
requiring an optimal set-up and expertise. |
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| ISSN: | 2249-782X 0973-709X |