Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GL...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09131-y |
| _version_ | 1818421848309760000 |
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| author | J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini |
| author_facet | J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini |
| author_sort | J. A. Gomez |
| collection | DOAJ |
| description | Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1. |
| first_indexed | 2024-12-14T13:16:53Z |
| format | Article |
| id | doaj.art-c82d0bc9e19e4ae49f59ed53ded7fe3d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:16:53Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c82d0bc9e19e4ae49f59ed53ded7fe3d2022-12-21T23:00:02ZengNature PortfolioNature Communications2041-17232019-03-0110111310.1038/s41467-019-09131-yVentral tegmental area astrocytes orchestrate avoidance and approach behaviorJ. A. Gomez0J. M. Perkins1G. M. Beaudoin2N. B. Cook3S. A. Quraishi4E. A. Szoeke5K. Thangamani6C. W. Tschumi7M. J. Wanat8A. M. Maroof9M. J. Beckstead10P. A. Rosenberg11C. A. Paladini12University of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioAging & Metabolism Research Program, Oklahoma Medical Research FoundationUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioAging & Metabolism Research Program, Oklahoma Medical Research FoundationDepartment of Neurology and the F.M. Kirby Neurobiology Center, Boston Children’s HospitalUniversity of Texas at San Antonio Neurosciences Institute, Department of Biology, University of Texas at San AntonioAstrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1.https://doi.org/10.1038/s41467-019-09131-y |
| spellingShingle | J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini Ventral tegmental area astrocytes orchestrate avoidance and approach behavior Nature Communications |
| title | Ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| title_full | Ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| title_fullStr | Ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| title_full_unstemmed | Ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| title_short | Ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| title_sort | ventral tegmental area astrocytes orchestrate avoidance and approach behavior |
| url | https://doi.org/10.1038/s41467-019-09131-y |
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